A study reports that several distinct mutations found in a subset of patients with acute myelogenous leukemia (AML) result in excess production of the same metabolite.
A study published online on February 8 in the Journal of Experimental Medicine (www.jem.org) reports that several distinct mutations found in a subset of patients with acute myelogenous leukemia (AML) result in excess production of the same metabolite.
The enzyme isocitrate dehydrogenase 1 (IDH1), which normally facilitates production of the metabolite {alpha}-ketoglutarate, is mutated in approximately 80% of secondary brain tumors. This mutant version of IDH1 promotes excess production of a different metabolite: R (-)-2-hydroxyglutarate (2-HG).
Research on Metabolite Profiling Makes Early Detection of Heart Attacks a Reality
Researchers at Massachusetts General Hospital, Charlestown, have developed a new method for early detection of a heart attack - metabolite profiling.
Researchers at Massachusetts General Hospital, Charlestown, have developed a new method for early detection of a heart attack - metabolite profiling.
Additional work is needed to understand if and how 2-HG influences brain cancer and/or leukemia progression. However, as these mutations have so far only been found in cancer, they may prove useful as drug targets.
New Test to Detect Metabolites Rapidly Developed
A new method to quickly and reliably detect metabolites, such as sugars, fatty acids, amino acids and other organic substances from plant or animal tissue samples has been identified
A new method to quickly and reliably detect metabolites, such as sugars, fatty acids, amino acids and other organic substances from plant or animal tissue samples has been identified
SAV
Immunosuppressive Action Of Fungal Metabolite - Gliotoxin
Researchers from Japan have recently demonstrated the first evidence that mast cell is a direct target of gliotoxin.
Researchers from Japan have recently demonstrated the first evidence that mast cell is a direct target of gliotoxin.
A New Chemical Compound Identified in Male Blue Crabs
Researchers at the University of Illinois at Chicago have discovered a chemical compound in male blue crabs.
Researchers at the University of Illinois at Chicago have discovered a chemical compound in male blue crabs.
