About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Sticky Glue Found in Bacteria may Pave Way for Superbug Vaccine

by Rajashri on September 11, 2008 at 3:01 PM
Font : A-A+

 Sticky Glue Found in Bacteria may Pave Way for Superbug Vaccine

A new study has said that the sticky glue secreted by the bacterium Staphylococcus aureus may hold the key for making an effective vaccine against MRSA (Methicillin-resistant Staphylococcus aureus).

While Staphylococcus aureus stay as a biofilm fairly harmlessly on most of the people who carry the bacteria, it may rarely cause severe and life threatening infections that are significant medical problems.

Advertisement

Many of these infections are made worse by the biofilm component of the overall disease, which helps to protect the bacteria from antibiotics.

"If individuals get infections many times, even after they have been cured by antibiotics, it indicates that their bodies have not become immune to Staph bacteria," said Professor Gerald Pier from Harvard Medical School in Boston, USA.
Advertisement

Staph bacteria tend to grow in cellular communities, particularly on medical devices commonly used on patients, like catheters, artificial heart valves, knees and hips, producing what are called biofilm type infections. All patients with these types of devices in them have an increased risk for Staph infections. Living in biofilms protects the bacteria from antibiotics, making treatment more difficult.

"To grow as a biofilm the bacteria must produce sticky factors, one of which is a type of complex sugar called PNAG. We are targeting this material as a possible vaccine, but natural exposure to the sugar compound does not result in most people and animals making an immune response that would protect them from attack by the bacteria or recurring infections," said Pier.

The scientists have manipulated the sugar chemically to discover that they can produce variant forms, which can be used as vaccines by causing the right type of immune response.

This approach has already been shown to work successfully in animal studies.

"We now have a way to tip the balance for resistance to infection back towards humans by vaccination. It is most likely that one or more forms of the vaccine will be prepared to test in humans to see which form is best to get the most desirable antibodies made," said Pier.

Besides, the scientists have also created an antibody with the desired properties to give to people if they have a high risk of getting a Staph infection, thus preventing infection.

"This antibody is being manufactured to start tests in humans in about 12 to 18 months. An effective antibody treatment for Staph infections could have a major benefit for anyone who enters a hospital or works in the community and is at risk of Staph infections," said Pier.

The study was presented at the Society for General Microbiology's Autumn meeting being held this week at Trinity College, Dublin.

Source: ANI
RAS/L
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Shigellosis MRSA - The Super Bug Drug Resistance - Antibiotic Resistance Food Safety for Health Antibiotics 

Recommended Reading
'Superbug' Breast Infections in Nursing Mothers can Be Overcome by Simple Antibiotics
New research by UT Southwestern Medical Center physicians suggests that conservative treatment can ....
MRSA Infections in Hospital ICUs can Be Lowered by 'Antibiotic Cycling'
Doctors at the University of Virginia Health System have successfully used a method called ......
Scientists Make Superbugs Explode and Die
In a breakthrough study, Scottish scientists have identified a chink in the protective shield of ......
Antibiotics
Antibiotics are among the most used and abused medications. This article explains some general featu...
Drug Resistance - Antibiotic Resistance
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and ...
MRSA - The Super Bug
MRSA infection is the most dreaded hospital or community acquired infection that can become ......
Shigellosis
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use