About My Health Careers Internship MedBlogs Contact us

Stem Cells Successful In Regrowing Center Of The Tooth

by Rishika Gupta on January 13, 2019 at 12:03 PM
Font : A-A+

Stem Cells Successful In Regrowing Center Of The Tooth

Stem cells with a little help from a bioengineering idea have successfully grown into a pulp-dentine complex, the structure which makes up the center of the tooth, finds a new study. The results of this study are published in the journal of Tissue Engineering.

The collaborative research between the Kornberg School of Dentistry and the College of Engineering uses stem cells to regrow the pulp-dentin complex that makes up the center of a tooth.


Undergoing a root canal may someday be a more pleasant experience, thanks to the work of a pair of researchers at Temple.

Associate Professor of Endodontology Maobin Yang, director of the Regenerative Health Research Laboratory at the Kornberg School of Dentistry, and Professor and Department Chair of Bioengineering Peter Lelkes have been collaborating on the research for three years. Yang and Lelkes' work focuses on using dental stem cells to regenerate the pulp tissue (including blood vessels and nerves) and dentin tissue that comprises the inside of a tooth.

"These two tissues come from a similar region and have a close relationship to each other. They make up the pulp-dentin complex," Yang explained. "If dentin decay is not that severe, the pulp can generate new dentin to repair it—all this happens naturally.

"But when we see patients, most have the pulp infected, so the nerve has to be taken out," he continued. "The root canal is then empty, so we currently fill up the root canal with inert treatment."

But Yang wanted to find a better treatment than the inert substance typically used in root canals. So he began to research the use of stem cells in conjunction with a small scaffold to simultaneously regenerate both tissues that form the pulp-dentin complex.

In generating the tissue using stem cells, there's one major problem. "When you put the components into the canal, they don't have spatial control, so they don't know where to grow the pulp and the dentin—the dentin outside and the pulp inside. So we need structure."

That's where Lelkes, a Laura H. Carnell Professor, came in: He worked with Yang to develop a bioengineered two-sided scaffolding to guide the tissue growth.

"The beauty of the system is that we have shown in vitro [test tube] that we can engineer a two-sided scaffold, and can guide the stem cells to differentiate into both pulp cells and dentin, producing odontoblasts that will eventually repair the root canal. We—our smart scaffold—can do this differentially with great efficacy."

Yang and Lelkes' partnership was born out of a friendship that occurred by happenstance: When Yang arrived at Temple six years ago, he initially worked out of a lab in Lelkes' department and found a mentor and friend in Lelkes. So when he needed bioengineering assistance in his research, he turned to Lelkes.

"This is one of the great cases when he says, 'Here, I have a clinical problem, let's try to find an engineering solution to this problem,'" Lelkes said.

The pair recently published their findings in the journal Tissue Engineering.

Yang said growing full teeth is still a bit distant in the research because the various materials that makeup teeth are complex and differ in their components. He told most research similar to his and Lelkes' focuses on regenerating parts of the tooth—and regenerating the nerve and dentin, as they are, is particularly valuable, as root canal treatment is such a common procedure.

The next step for the researchers is to test the tissue growth technique in animal models.

"I believe in the next 10 years, or even sooner, when patients come to the endodontist for a root canal treatment, we will be able to provide an alternative, equivalent or even better treatment modality, which is to regrow the nerves and the blood vessels and to grow new pulp back into your tooth, instead of using inert material," Yang said. "With investments and with lots of research, I believe that we will get there soon."

Source: Newswise

News A-Z
News Category
What's New on Medindia
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
Emotional Healing
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Loose Teeth Stem Cells - Cord Blood Tooth Decay Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Dental Check-Up Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine Root Canal Treatment 

Recommended Reading
Stem Cells Allow Diseased Heart to Heal Themselves
Developing heart stem cells allow human heart to heal themselves and reduce the need for bypass ......
Placenta-derived Stem Cells for Regeneration of Heart Disease
The placenta can be readily collected at birth and the cells harvested for pediatric reparative ......
Placental Stem Cells Repair and Regenerate Heart Tissue
Placenta-derived mesenchymal stem cells (pMSCs) form cell sheets that could be implanted in ......
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Dental Check-Up
It is commonly recommended that you visit the dentist twice a year to clean your teeth and gums and ...
Loose Teeth
Looseness of teeth is caused by a disease of the periodontium and includes the tissues surrounding t...
Root Canal Treatment
Root Canal Treatment or Endodontic therapy is a procedure done to remove the infected pulp and save ...
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Tissue Engineering and Regenerative Medicine
This new field is an amalgamation of biology, medicine and engineering, and is believed to have mind...
Tooth Decay
Tooth decay in toddlers, children and adults, also called dental caries, is a bacterial infection ca...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use