About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Stem Cells Can be Isolated from Umbilical Cord Blood By New Recombinant Antibody

by Rukmani Krishna on September 6, 2013 at 9:37 AM
Font : A-A+

 Stem Cells Can be Isolated from Umbilical Cord Blood By New Recombinant Antibody

A new recombinant antibody can detect and isolate mesenchymal stem cells (MSCs). MSCs are a nonembryonic source of stem cells with promising applications in tissue engineering, blood stem cell transplantation, and treatments for immune-mediated disorders. The antibody recognizes an i blood group antigen present on MSCs in umbilical cord blood, as described in a study published in BioResearch Open Access, a peer-reviewed journal from Mary Ann Liebert, Inc. The article is available free on the BioResearch Open Access website.

Tia Hirvonen and coauthors from the Finnish Red Cross Blood Service, Glykos Finland Ltd., and Biova Ltd. (Helsinki), and VTT Technical Research Center of Finland (Espoo), identified a blood donor with high levels of antibody to the i blood group antigen. No antibodies recognizing this antigen are commercially available at present.

Advertisement

In the article "Production of a Recombinant Antibody Specific for i Blood Group Antigen, a Mesenchymal Stem Cell Marker," the authors explain that the i antigen can serve as a marker to detect and isolate MSCs in umbilical cord blood (UCB). They describe the use of antibody phage display technology to produce a recombinant anti-i antibody that recognizes i antigen on the surface of UCB-MSCs as well as on red blood cells.

"The authors have used antibody phage display technology to generate an anti-i antibody," says BioResearch Open Access Editor Jane Taylor, PhD, MRC Centre for Regenerative Medicine, University of Edinburgh, Scotland. "The advantage of this technique is that antibodies against poorly immunogenic molecules can be generated, as an immunization strategy is not required. The availability of an anti-i antibody has the potential to improve the isolation efficiency of MSCs from umbilical cord blood samples."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Thalassemia Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine Stem Cells Exomphalos Blood in Stools - Symptom Evaluation 

Recommended Reading
Research Says Fetal Tissue-Derived Stem Cells may be Ideal Source for Repairing Tissues and Organs
Italian researchers say that multipotent fetal dermal cells (MFDCs) may be an ideal source for cell ...
Blood in Stools - Symptom Evaluation
Blood in stools results from bleeding that arises from any part of the digestive tract. Causes of bl...
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Exomphalos
Exomphalos is a birth disorder in which the abdominal contents herniate into the umbilical cord thro...
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
Tissue Engineering and Regenerative Medicine
This new field is an amalgamation of biology, medicine and engineering, and is believed to have mind...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use