New Stem Cell Research Offers Clues to Cancer Treatment

by Vishnuprasad on December 20, 2014 at 3:32 PM

New Stem Cell Research Offers Clues to Cancer Treatment
A latest research by Joshua Brickman and his research team from Danish Stem Cell Center (Danstem) at the University of Copenhagen specifically has found that inhibiting or blocking stem cells ability to make a specific decision, leads to better cell growth and could lead to defined ways to differentiate stem cells.

This research is the first comprehensive analysis of a pathway important for stem and cancer cell decisions known as Erk. As a result this work could contain clues to cancer treatment as well as helping to establish a platform to make stem cell treatments for gut related disorders like the pancreas or the liver.

The research results have just been published in Cell Reports.

Blocking Choices

"If you block all the choices they can make, they stay in the stem cell state. If you only allow them one door to exit from the stem cell state, you should be able to make particular cell types more efficiently. So if you only leave one door open then it's the path of least resistance and when you give them a push they really go," says Professor Joshua Brickman.

As embryonic stem cells can become any cell type in the body, they have to make choices. Based on this research, it appears that blocking these choices is the key to making them grow as stem cells. In other words, if these choices are removed the cells simply reproduce more stem cells.

Embryonic Stem Cells

In an embryo, cells like embryonic stem cells exist very briefly, quickly differentiating into other cell types that will go on to make the entire organism. This new study shows that chemicals traditionally used to grow embryonic stem cells act to block different choices that they would normally make. By blocking these choices, scientists can then transform these cells from the embryo into embryonic stem cells and grow them indefinitely in a dish.

"This creates an intellectual framework to help establish tissue techniques for other stem cells populations and represents a new paradigm for how we think about embryonic stems cells and how we maintain them," says Postdoc William Hamilton from DanStem.

By forcing a cell to go through a particular door by virtue of closing all the other doors, the scientists know need to know what the door is. "On a scientific level we would now like to know what the lock and key looks like and then we can understand how many more doors there are," adds Professor Joshua Brickman.

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Plant-Based Diet may Reduce the Risk of COVID-19
Lower Respiratory Tract Infections Linked to Obstructive Sleep Apnea in Children
Type 2 Diabetes can be Controlled by Unripen Green Jackfruit Flour
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Stem Cells - Cord Blood Stem Cells - Fundamentals Cancer and Homeopathy Parkinsons Disease Surgical Treatment Genetics and Stem Cells Cancer Facts Cancer Tattoos A Body Art Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine 

Recommended Reading
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Bone Marrow Aspiration and Biopsy
Bone marrow biopsy and aspiration is the removal of some bone marrow tissue for diagnosis and ......
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...
Tissue Engineering and Regenerative Medicine
This new field is an amalgamation of biology, medicine and engineering, and is believed to have mind...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use