Statins Can Reduce Infection Risk in Stroke Patients

People who have suffered an ischemic stroke can reduce their risk of infections by taking statins, said a new study.

Doug Weeks, an adjunct professor in the Elson S. Floyd College of Medicine and director of research at St. Luke's Rehabilitation Institute, analyzed the records of more than 1,600 hospitalized patients who suffered an ischemic stroke and found statins reduced the risk of infection by 58 percent.

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The results of J-STARS study led to the hypothesis that statins reduce the occurrence of strokes due to larger artery atherosclerosis.

‘One-third to almost one-half of stroke patients develops infections, as stroke weakens immune system making them more susceptible to diseases. Statins can reduce infection risk in these patients.’

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Ischemic strokes are due to blockage of a vessel that supplies blood to the brain. His findings appear online this month in the Journal of Stroke and Cerebrovascular Diseases.

"If patients had statins before there was evidence of an infection, there was a reduced risk that they would actually develop an infection," said Weeks.

Statins are typically used to lower cholesterol levels to reduce the risk of cardiovascular disease. But in the past decade, said Weeks, researchers have noticed that they also have anti-inflammatory properties in humans that can benefit the body's response to infection.

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Statin use was also associated with reduced risk of death during and immediately after coronary artery bypass surgery (CABG).

Weeks analyzed data of hospitalized stroke patients and saw that those on statins upon admission or early in their stay had significantly lower risk for developing infections than those put on statins later in their hospitalization or not at all.

Weeks controlled for other possible influences like the severity of strokes, age and the presence of other conditions like diabetes.He and his colleagues also noticed that the timing of the drug was a major factor.

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Statins used to lower cholesterol in patients at risk for heart disease, appeared to provide an increase in overall survival for those cancer patients who received them.

"The administration of statins relative to infection is critically important," he said. "We've been able to establish that if statins are given early, before infection can occur, the risk of infection is substantially reduced. However, this relationship needs to be tested in more rigorous placebo-controlled studies to see if this benefit with statins is maintained.”

"Estimates vary, but one-third to almost one-half of stroke patients develop infections," he said. The infections could be introduced through tubes or catheters. There are also indications that stroke subdues the body's immune system, making a patient more prone to infection.

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Source-Eurekalert