Men with type 2 diabetes, who already have borderline-low testosterone, could benefit from soy protein supplements which contain natural estrogens and do not reduce testosterone levels in them, revealed a new study. The results were presented Saturday at the joint meeting of the International Society of Endocrinology and the Endocrine Society: ICE/ENDO 2014 in Chicago.
"Because soy contains phytoestrogens that are similar to the female hormone estrogen, it was not known whether consumption of soy could reduce testosterone levels in men with Type 2 diabetes, who are at increased risk of low testosterone," said the study's lead investigator, Thozhukat Sathyapalan, MD, an endocrinologist researcher at Hull York Medical School, University of Hull, Hull, U.K.
"It was important to know this because prior studies have found that daily consumption of soy reduces the risk of Type 2 diabetes and heart problems. Our study found that soy protein and phytoestrogen supplementation is safe in diabetic men and may improve their diabetes control and their risk factors for heart disease," Sathyapalan said.
The men had testosterone blood tests before and after treatment at the same time of day. Both groups experienced an increase in total testosterone level, the investigators reported. On average, testosterone level increased from 9.8 to 11.3 nmol/L in the soy protein-phytoestrogen group and from 9.2 to 10.3 nmol/L in the group receiving only soy protein.
Sathyapalan said it is unclear why testosterone levels rose, but it could be a direct effect of soy.
Soy protein with phytoestrogens also improved diabetes control much better than did soy protein alone. Specifically, the first group significantly lowered their fasting blood glucose (sugar) levels and hemoglobin A1c, a measure of blood sugar control over the past three months, as well as fasting insulin levels and estimated insulin resistance, which showed an improved use of the hormone insulin. Neither group lost or gained weight, according to Sathyapalan.
In addition, the phytoestrogen-containing soy protein reportedly led to better improvements in certain cardiovascular risk factors, he said. These included triglycerides—a type of fat in the blood—and high-sensitivity C-reactive protein, which measures inflammation in the body and is a predictor of heart disease risk. Total cholesterol and "bad" (LDL) cholesterol levels rose (worsened) in both groups but not enough to be statistically significant, according to Sathyapalan.
Both soy protein supplements significantly improved diastolic blood pressure (the bottom number in a blood pressure reading) but not systolic blood pressure (the top number).