About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

See-Through Organs to Better Diagnose Diseases on the anvil

by Kathy Jones on August 1, 2014 at 11:18 PM
 See-Through Organs to Better Diagnose Diseases on the anvil

Researchers hope to come up with new methods that will allow physicians to see through organs and the body to visualize long-range connections between cells, which can lead to better diagnosis of diseases.

Senior study author Viviana Gradinaru of the California Institute of Technology said that although the idea of tissue clearing had been around for a century, to their knowledge, this was the first study to perform whole-body clearing, as opposed to first extracting and then clearing organs outside the adult body.

Advertisement

Gradinaru said that their methodology had the potential to accelerate any scientific endeavor that would benefit from whole-organism mapping, including the study of how peripheral nerves and organs could profoundly affect cognition and mental processing, and vice versa.

In the new study, the researchers set out to make clarity suitable for whole organs and bodies, in part by making the process faster. First, they identified the optimal hydrogel that allows detergents to quickly remove lipids from tissue using an approach named passive clarity technique (PACT).
Advertisement

Gradinaru added that their easy-to-use tissue clearing protocols, which employed readily available and cost-effective reagents and equipment, will make the subcellular interrogation of large tissue samples an accessible undertaking within the broader research and clinical communities.

The researchers also developed a recipe for refractive index matching solution (RIMS), which enables the long-term storage of cleared tissue and imaging thick, cleared tissue using a conventional confocal microscope.

The study is published in the journal Cell.

Source: ANI
Font : A-A+

Advertisement

Advertisement
Advertisement

Latest Research News

Brain Circuits That Shape Bedtime Rituals in Mice
New study sheds light on the intrinsic, yet often overlooked, role of sleep preparation as a hardwired survival strategy.
NELL-1 Protein Aids to Reduce Bone Loss in Astronauts
Microgravity-induced bone loss in space, can be reduced by systemic delivery of NELL-1, a protein required for bone growth and its maintenance.
Connecting Genetic Variants to the Alzheimer's Puzzle
Researchers establish connections between Alzheimer's-linked genetic alterations and the functioning of brain cells.
Gene Therapy Sparks Spinal Cord Regeneration
Team at NeuroRestore introduces a groundbreaking gene therapy that has effectively promoted nerve regrowth and reconnection, post spinal cord injury.
Unlocking the Gut Microbiome's Influence on Bone Density
Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
MediBotMediBot
Greetings! How can I assist you?MediBot
×

See-Through Organs to Better Diagnose Diseases on the anvil Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests