Along with several other factors, both severely restricted and excessive fetal growth may be associated with stillbirth, reveals a study by US researchers published in this week's PLOS Medicine.
Radek Bukowski and colleagues from the NICHD Stillbirth Collaborative Research Network investigated the fetal growth abnormalities associated with stillbirth using a new approach developed by the Stillbirth Collaborative Research Network to estimate gestational age.
Using this approach the authors investigated all the stillbirths, and a sample of live births, which occurred over 2 and a half years at 59 hospitals in five US regions.
Although the accuracy of these findings is likely to be affected by aspects of the study design, these findings suggest that, contrary to current practices, strategies designed to prevent stillbirth should focus on identifying both severely SGA and severely LGA fetuses.
The authors say: "When accounting for time of death and using norms developed in normal pregnancies, both SGA and LGA birth weights were associated with stillbirth in our study.
They continue: "The association is mainly related to severe SGA and LGA pregnancies, with birth weights either below the 5th or above the 95th percentile. Thus, classifying 10% of pregnancies as abnormally grown has the potential to identify 44%-46% of future stillbirths."