About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Scientists Showcase Embryonic Heart Regeneration in Mammals

by Rajashri on October 15, 2008 at 2:49 PM
Font : A-A+

 Scientists Showcase Embryonic Heart Regeneration in Mammals

Embryonic mouse heart has the capacity to regenerate, a phenomenon that has thus far been attributed to non-mammalian species, an international team of researchers has revealed.

In their research paper, published in the journal Developmental Cell, the researcher write that their study suggests that the embryonic heart can replace diseased tissue through compensatory proliferation of healthy cells.

Advertisement

Disorders of the mitochondria, a cell structure required for energy production, are one of the leading causes of fatal early onset cardiomyopathies.

Professor Timothy C. Cox and his colleagues from the University of Washington in Seattle set out to probe how mutations, which interfere with mitochondrial function, impact the heart during development
Advertisement

The researchers used a heart-specific knockout approach in mice to inactivate a gene crucial for normal mitochondrial function.

Their experimental methods established embryonic female mice with mosaic hearts composed of mixed cell populations: half normal and half "diseased".

However, at birth, the diseased cells represented only about 10 per cent of the cardiac tissue.

The researchers further observed that increased proliferation of healthy heart cells was responsible for this change, and led to a fully functional heart.

Despite normal cardiac function early in life, according to the team, over 40 per cent of adult mice prematurely developed cardiac pathologies, which might indicate a hitherto unsuspected embryological origin for early onset cardiac disease in humans.

"Our findings reveal an impressive regenerative capacity of the foetal heart that can compensate for an effective loss of half of the cardiac tissue," Professor Cox said.

"To the best of our knowledge, this represents the first in vivo demonstration of selection against diseased tissue during embryonic heart development," the researcher added.

Based on their observations, the researchers came to the conclusion that some cell populations within the heart were better able to regenerate than others, and that those others were likely to be the source of later pathology.

Source: ANI
RAS/SK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Heart Healthy Heart Statins Mitral Valve Prolapse Aortic Valve Stenosis Pericarditis 

Recommended Reading
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Bone Marrow Transplantation - Animation
Animation and slides providing graphic explanation of Bone Marrow Transplantation (BMT)/Stem Cell ....
Sperm Cells Could Be Turned into Stem Cells
It may be possible to turn the sperm cells found in testicles into stem cells, German and UK ......
Aortic Valve Stenosis
Aortic valve Stenosis is an abnormal narrowing of the c valve. Symptoms include angina, and that of ...
Mitral Valve Prolapse
Mitral Valve Prolapse is a relatively common condition and causes leakage of blood through the valve...
Pericarditis
Pericarditis occurs when the pericardium gets inflamed. Pericarditis is characterized by severe ches...
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)