About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Stem Cells may Act as Mediators in Gene Therapy to Injured Nervous System

by Rajashri on October 15, 2008 at 2:52 PM
Font : A-A+

 Stem Cells may Act as Mediators in Gene Therapy to Injured Nervous System

Transplanted bone marrow stem cells can attach themselves to injured areas in the brain or spinal cord., US scientists have indicated

Amyotrophic lateral sclerosis (ALS) researchers at The Methodist Hospital in Houston believe that experts trying to find a way to deliver gene therapy may finding their research interesting.

Advertisement

Study leader Dr. Stanley H. Appel says that such "Trojan horse" cells may improve the ability to deliver gene therapy to the brain and spinal cord.

The researcher, who is the co-founder and co-director of the Methodist Neurological Institute at The Methodist Hospital, has revealed that the original intent behind the study was to see whether transplanted bone marrow stem cells in six patients with sporadic ALS would suppress neuroinflammation, and improve the patients' clinical outcomes.
Advertisement

Though the study showed no benefit in fighting the disease, the researchers found that transplanting bone marrow stem cells that were closely matched to the patients' own bone marrow allowed for a significant percentage of those cells to travel to, and reside in the brain or spinal cord.

However, it is clear from the study that unless the bone marrow stem cells are engineered to secrete neuroprotective factors, such transplants are not likely to be beneficial in human ALS.

"Our courageous ALS patients committed themselves to helping search for meaningful therapies for this devastating disease," said Appel, lead author and chairman of Neurology at Methodist.

"With their help, we've shown that these transplanted stem cells can potentially be used to deliver future drugs. These findings open the window in terms of where we can go next," he added.

Appel said that his team focused on bone marrow because of all stem cells, which can offer a readily available source for potential use in the development of therapies, drug delivery, and drug administration in ALS and other neurodegenerative diseases.

The study has been published in the journal Neurology.

Source: ANI
RAS/SK
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Stem Cells - Cord Blood Stem Cells - Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Reiki and Pranic Healing Genetic Testing of Diseases Pancreas Bone Marrow Transplantation Tissue Engineering and Regenerative Medicine 

Recommended Reading
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is ......
Bone Marrow Transplantation - Animation
Animation and slides providing graphic explanation of Bone Marrow Transplantation (BMT)/Stem Cell ....
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...
Genetic Testing of Diseases
Genetic testing helps to confirm a genetic condition in an individual and involves q complex laborat...
Tissue Engineering and Regenerative Medicine
This new field is an amalgamation of biology, medicine and engineering, and is believed to have mind...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use