A new tool that illuminates connections between stem cells and cancer, has been developed by scientists.
Researchers have been successful in breaking apart human prostate tissue, extract the stem cells in the tissue, and alter those cells genetically so that they spur cancer.Many tissues contain pools of stem cells that replenish the tissue when it's damaged or when changes take place. For example, stem cells in the skin produce new cells to replace those irreparably damaged by the sun, and stem cells in the breast create milk-producing cells when a woman is pregnant. A characteristic of these stem cells is that they self-renew. This means that in addition to making cells with a specific function, they also make many new stem cells.
Growing evidence suggests that these self-renewing cells are also linked to cancer. According to Owen Witte, a Howard Hughes Medical Institute investigator at the University of California, Los Angeles, they tend to collect mutations and not much separates tumor cells, with their capacity for unchecked growth, from healthy, tissue-forming stem cells.
Witte says: "These cells have a huge capacity for self-renewal, and when the pathways that control self-renewal are augmented or changed, they can form tumors."
Numerous scientists believe that although tumors are made up of many cells, only the tumor cells derived from stem cells contribute to the growth of the tumour. For certain cancers, such as breast cancer and leukemia, that idea is well established. For others, such as prostate cancer, which Witte studies, the data are not conclusive.
Witte's team has been analyzing the relationship between tissue stem cells and cancer stem cells in the prostate. They have been attacking this problem by dividing mouse prostate tissue into its component cell types, culturing those cells, and then reassembling them to understand how they interact. Now, for the first time, they've accomplished that feat with human tissue. They have successfully engineered specific genetic changes into human prostate stem cells to transform them into cancer cells.
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He says: "Here you can pre-program the genetic buffet, and then evaluate a compound in the face of those specific changes."
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Witte says: "The field of cancer research has produced a significant number of major new targeted therapies.
"Now we have to understand how best to use those therapies."
Source-ANI
TRI