About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Schizophrenia Risk Influenced by Genes

by Rajshri on August 1, 2008 at 1:40 PM
Font : A-A+

 Schizophrenia Risk Influenced by Genes

An inherited vulnerability to schizophrenia has been uncovered by three new studies that were published Wednesday.

Among people with schizophrenia, deletions and duplications are more common in key locations of the genetic code compared to otherwise healthy counterparts, according to the papers, released by the London-based journal Nature.

Advertisement

The studies cast a net through the genomes of thousands of people with schizophrenia and a large number of "controls" for comparison.

Schizophrenia is a complex brain disorder, characterised by delusions and hallucinations, that strikes around one person in 100 at some point in their lives -- usually in late adolescence or early adulthood -- and with often devastating results.
Advertisement

Scientists have long suspected that genes play a far more important role in the disease than environmental factors.

By some estimates, genetic factors could account for 73 to 90 percent of cases, but no big culprit genes have emerged so far. This has led investigators to look at a range of smaller, subtler genetic changes, which quite likely are linked, and such tiny variations can be difficult to detect.

The new studies, conducted by three international teams of scientists, point to locations on Chromosomes 1, 15 and 16, where telltale DNA changes were about 15 percent more frequent among people with schizophrenia.

They also confirmed earlier work that pointed the finger at an area on Chromosome 22.

Researchers said they had unlocked some fundamental knowledge about schizophrenia, but urged caution.

"The findings are impressive and (represent) hugely important leaps towards understanding the origins of schizophrenia," said Michael O'Donovan, a professor at Cardiff University in Wales, which is part of the International Schizophrenia Consortium, gathering 11 research institutes.

"But since only a small amount of the genetic risk for schizophrenia has been accounted for, they are not ready to be applied for genetic testing."

A number of biotech companies are now offering DNA tests for psychiatric disorders, although many experts say the genetic causes of mental ill-health remain poorly understood and inaccurate results could spur panic, confusion or complacency.

Source: AFP
RAS/M
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Schizophrenia Mental Health - Neurosis vs Psychosis Schizoaffective Disorder Mind-wandering Paranoia Anosognosia Antipsychotic Medications 

Recommended Reading
Schizophrenia
Schizophrenia is a mental disorder characterized by symptoms of thought, behavior and social ......
Scientists a Step Closer to Understanding Genetics of Schizophrenia
American scientists have moved a step closer to unravelling how abnormal microRNAs, molecules that ....
Enzyme That may Contribute to Schizophrenia, Psychiatric Disorders Identified
A new study on mice has found that the lack of an enzyme that contributes to Alzheimer's disease ......
Anosognosia
Anosognosia is the lack of awareness or insight in a patient to understand that he/she has a disease...
Antipsychotic Medications
Antipsychotics are the class of drugs which help in treating mental disorders like schizophrenia, bi...
Mental Health - Neurosis vs Psychosis
Mental well-being is a concern and abnormal coping of emotions can lead to neurosis or psychosis. Me...
Mind-wandering
Mind wandering is a spontaneous and unintentional shifting of attention of thoughts from a primary t...
Paranoia
Paranoia is a false belief where the individual feels unfairly targeted or persecuted by everyone el...
Schizoaffective Disorder
Schizoaffective disorder is a serious mental disorder in which the individual reflects symptoms that...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use