Scans may Predict Best Treatment for Depression

Brain activity scans may help predict the efficiency of antidepressant medication or psychotherapy as a treatment for depression, a new study finds. "Our goal is to develop reliable biomarkers that match an individual patient to the treatment option most likely to be successful, while also avoiding those that will be ineffective," explained Helen Mayberg, M.D., of Emory University, Atlanta, a grantee of the NIH's National Institute of Mental Health.

Mayberg and colleagues report on their findings in JAMA Psychiatry, June 12, 2013.

"For the treatment of mental disorders, brain imaging remains primarily a research tool, yet these results demonstrate how it may be on the cusp of aiding in clinical decision-making," said NIMH Director Thomas R. Insel, M.D.

Currently, determining whether a particular patient with depression would best respond to psychotherapy or medication is based on trial and error. In the absence of any objective guidance that could predict improvement, clinicians typically try a treatment that they, or the patient, prefer for a month or two to see if it works. Consequently, only about 40 percent of patients achieve remission following initial treatment. This is costly in terms of human suffering as well as health care spending.

		IMAGE: Brain PET scans prior to treatment predicted whether a patient's depression would best respond to an antidepressant or a psychotherapy. Higher resting activity in the right front insula identified cognitive... Click here for more information.

Source-Eurekalert