About Careers Internship MedBlog Contact us

Retinal Transplants: Helping the Blind to See

by Tanya Thomas on September 10, 2008 at 9:22 AM
 Retinal Transplants: Helping the Blind to See

Retinal transplant seems to be the new buzzword doing the rounds in medical circles nowadays after eye surgeons asserted that they may be able to restore sight to some blind people with such a transplant mechanism.

Preliminary research has shown encouraging results with transplantation of retinal cells in patients with blindness caused by retinitis pigmentosa (RP) and age-related macular degeneration (AMD).


In the study, Dr. Norman D. Radtke of University of Louisville, Kentucky, lead author of the study and colleagues performed the experimental transplant procedure in ten patients with vision loss resulting from retinal degeneration.

Each of the patients in the trial received a small 4-millimetre square of retinal tissue, complete with retinal progenitor cells and the retinal pigment epithelium that nourishes them.

The tissues were placed in the sub-retinal space beneath the fovea, the area of the retina responsible for sharp central vision.

The researchers found that seven of the subjects experienced an improvement in their visual acuity.

The results of phase II trial may seem to boost the chances of restoring vision in sufferers of RP and AMD but it is far from clear just how much hope this research really offers.

"I think this approach will never work as a standard clinical therapy," Nature quoted Marco Zarbin director of the Institute of Ophthalmology and Visual Sciences at New Jersey Medical School, in Newark, as saying.

He said that one reason is the fact that the transplanted tissue is obtained from aborted fetuses.

"Even if it proves to work wonderfully, the number of patients that would need to be treated worldwide or even in the United States alone would be in the millions," he said.

There simply wouldn't be enough donors available, and the logistics of getting the ethical approval to use them would act as a major barrier to treatment, Zarbin added.

Another concern is the efficacy of the procedure. Despite 20 years of research on animals, by co-authors Robert Aramant at research firm Ocular Transplantation, also in Louisville, and Magdalene Seiler at the University of California, Irvine, there is still no clear evidence that the improved vision in humans is directly due to the transplanted photoreceptor cells replacing the function of host cells within the retina.

And major issue is that the improved visual acuity seems to only last for a couple of years.

Zarbin said that the real value of this trial is the demonstration that cells can be placed in the sub-retinal space without any adverse reaction.

This holds promise for other possible forms of cell-based treatment currently being explored, such as introducing stem cells into the retina and getting them to differentiate into new photoreceptors.

The study is published in the August issue of the American Journal of Ophthalmology1.

Source: ANI
Font : A-A+



Recommended Readings

Latest Research News

Insight into Cellular Stress: Mechanisms Behind mRNA Sequestration Revealed
The discovery deepens our understanding of m6A biology and stress granule formation, with implications for neurodegenerative diseases.
Disrupted Circadian Rhythm Elevates the Risk of Parkinson's Disease
Trouble with sleep and the body's clock may increase your risk for Parkinson's, as per a new study.
A Wake-Up Call for Women — Hot Flashes Could Point to Alzheimer's Risk
New study uncovers a link between nocturnal hot flashes and Alzheimer's risk in menopausal women, suggesting a potential biomarker.
Breakthrough Brain-Centered Approach Reduces Chronic Back Pain
Our discovery revealed that a minority of individuals attributed their chronic pain to their brain's involvement.
New Statement to Protect Athletes' Health Published
Relative Energy Deficiency in Sport syndrome is overlooked by athletes and can be worsened by 'sports culture' due to its perceived short-term performance benefits.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

Retinal Transplants: Helping the Blind to See Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests