About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Researchers Find A New Way to Generate Insulin-producing Cells in Type 1 Diabetes

by Dr. Enozia Vakil on August 1, 2014 at 6:52 PM
Font : A-A+

 Researchers Find A New Way to Generate Insulin-producing Cells in Type 1 Diabetes

A peptide known as caerulein can convert existing pancreatic cells to cells destroyed in type 1 diabetes insulin producing cells, a new study has found. The study, published online July 31 in Cell Death and Disease, suggests a new approach to treating the estimated 3 million people in the U.S., and over 300 million worldwide, living with type 1 diabetes.

"We have found a promising technique for type 1 diabetics to restore the body's ability to produce insulin. By introducing caerulein to the pancreas we were able to generate new beta cells — the cells that produce insulin — potentially freeing patients from daily doses of insulin to manage their blood - sugar levels." said Fred Levine, M.D., Ph.D., professor and director of the Sanford Children's Health Research Center at Sanford - Burnham.

Advertisement

The study first examined how mice in which almost all beta cells were destroyed — similar to humans with type 1 diabetes — responded to injections of caerulein. In those mice, but not in normal mice, they found that caerulein caused existing alpha cells in the pancreas to differentiate into insulin - producing beta cells. Alpha cells and beta cells are both endocrine cells meaning they synthesize and secret hormones — and they exist right next to one another in the pancreas in structures called islets. However, alpha cells do not normally become beta cells.

The research team then examined human pancreatic tissue from type 1 diabetics, finding strong evidence that the same process induced by caerulein also occurred in the pancreases of those individuals. The process of alpha cells converting to beta cells does not appear to have any age limitations — it occurred in young and old individuals — including some that had type 1 diabetes for decades.
Advertisement

"When caerulein is administered to humans it can cause pancreatitis. So our next step is to find out which molecule(s) caerulein is targeting on alpha cells that triggers their transformation into beta cells. We need to know this to develop a more specific drug," said Levine.

Caerulein is a peptide originally discovered in the skin of Australian Blue Mountains tree frogs. It stimulates gastric, biliary, and pancreatic secretions, and has been used in humans as a diagnostic tool in pancreatic diseases.

"In addition to creating new beta cells, another issue that needs to be addressed to achieve a cure for type 1 diabetes is that any new beta cells will be attacked by the autoimmune response present in every patient with type 1 diabetes. We are currently working with Linda Bradley, Ph.D., professor in the Immunity and Pathogenesis Program, and co - author of the study, to couple our approach with an approach to reining in the autoimmune response," added Levine.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetic Retinopathy Diabetes Diabetic Diet Otitis Media Parkinsons Disease Surgical Treatment Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Diabetes and Exercise Stress Relief Through Alternative Medicine Stress and the Gender Divide 

Recommended Reading
Remedies to Treat Diabetes Naturally
An article about the natural remedies available at home to treat diabetes effectively and ......
Diabetes Screening
Diabetes screening is done using blood tests like fasting blood sugar and hemoglobin A1c levels. ......
Diabetes
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, sy...
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the...
Diabetic Diet
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nut...
Diabetic Retinopathy
The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with ......
Insulin Delivery Devices
Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed ...
Otitis Media
Middle ear infection, or otitis media, is a common type of infection that may or may not accompany t...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use