About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Research Sheds Light on Outcomes of Steroid Therapy Following Surgery for Infants With Bile Duct Disorder

by Kathy Jones on May 4, 2014 at 5:53 PM
Font : A-A+

 Research Sheds Light on Outcomes of Steroid Therapy Following Surgery for Infants With Bile Duct Disorder

A study in the May 7 issue of JAMA, a theme issue on child health, says that the administration of high-dose steroid therapy following surgery did not significantly improve bile drainage after 6 months among infants who underwent surgery to repair bile ducts that do not drain properly.

This issue is being released early to coincide with the Pediatric Academic Societies Annual Meeting.

Advertisement

Biliary atresia progresses to end-stage liver disease (cirrhosis) in more than 70 percent of affected children and is the leading indication for pediatric liver transplantation in the world, accounting for about 50 percent of liver transplants in children. Hepatoportoenterostomy (surgery to improve bile drainage) results in successful bile drainage in only about half of patients with biliary atresia treated in the United States, underscoring the need for additional therapies to improve survival without liver transplantation, according to background information in the article. There have been conflicting reports regarding the effectiveness of the use of corticosteroids to improve bile flow following surgery.

Jorge A. Bezerra, M.D., of Cincinnati Children's Hospital Medical Center, Cincinnati, and colleagues randomly assigned 140 infants (average age, 2.3 months) to receive high-dose steroid therapy or placebo following surgery to improve bile drainage.
Advertisement

The researchers found that the proportion of infants with improved bile drainage was not significantly improved by steroids at 6 months following surgery (58.6 percent of steroids group vs 48.6 percent of placebo group). The adjusted absolute risk difference was 8.7 percent.

Survival without liver transplantation at 2 years of age for infants treated with steroids was nearly identical to those who received placebo (58.7 percent vs. 59.4 percent). Serious adverse events were com¬mon in both treatment groups (81.4 percent for steroids vs 80.0 percent for placebo); however, infants treated with steroids experienced their first serious adverse events earlier than those receiving placebo.

"Based on the strength of the evidence, the addition of high-dose steroids as an adjuvant [supplemental] treatment for infants with biliary atresia after hepatoportoenterostomy cannot be recommended," the authors write.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First Dose of COVID-19 Vaccines May Improve Mental Health
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cannabis Drug Abuse Patent Ductus Arteriosus Reiki and Pranic Healing Anabolic Steroids Bile Duct Cancer Sclerosing Cholangitis Ampullary Cancer Alagille Syndrome 

Recommended Reading
Intussusception in Children
Intussusception is condition where one segment of the intestine infolds into the adjacent segment .....
Paediatric Laparoscopic Surgery / Key Hole Surgery
Medindia provides a very interesting Paediatric Laparoscopic surgery section for doctors...
Small bowel atresia
The small bowel is the section of bowel between the stomach and the large bowel (colon). It is ......
Alagille Syndrome
Alagille syndrome is a rare genetic disorder that is caused by hereditary or spontaneous mutations i...
Ampullary Cancer
Ampullary cancer is a rare cancer of the ampulla of Vater that connects the common bile duct and pan...
Anabolic Steroids
Anabolic steroids can produce power- packed, adrenaline – pumping performances but they also reflect...
Bile Duct Cancer
Bile duct cancer occurs either within the liver or the point where the bile ducts emerge from the li...
Cannabis
Cannabis has a long history of medicinal, recreational, and industrial use and comes from a bushy pl...
Drug Abuse
The use of Drugs for reasons other than its prescribed recommendation, is known as Drug abuse or sub...
Patent Ductus Arteriosus
Patent Ductus Arteriosus is a congenital defect of the heart where the fetal passage between pulmona...
Sclerosing Cholangitis
Sclerosing cholangitis is a liver disease characterized by inflammation and scarring of bile ducts w...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use