About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Regeneration of Heart Cells Possible in Mice With the Help of Specialized Protein, ERBB2

by Bidita Debnath on April 14, 2015 at 9:46 PM
Font : A-A+

Regeneration of Heart Cells Possible in Mice With the Help of Specialized Protein, ERBB2

A team of researchers at Weizmann Institute has regenerated heart cells in adult mice using a specialized protein called ERBB2.

When a heart attack strikes, heart muscle cells die and scar tissue forms, paving the way for heart failure, but research provides insight into the question of why the mammalian heart fails to regenerate, on one hand, and demonstrated, in adult mice, the possibility of turning back this fate.

Advertisement

Researcher Eldad Tzahor thought that part of the answer to the regeneration puzzle might lie in his area of expertise: embryonic development, especially of the heart. Indeed, it was known that a protein called ERBB2, which is well studied because it can pass along growth signals promoting certain kinds of cancer, plays a role in heart development.

ERBB2 is a specialized receptor, a protein that transmits external messages into the cell, and generally works together with a second, related, receptor by binding a growth factor called Neuregulin 1 (NRG1) to transmit its message. NGR1 is already being tested in clinical studies for treating heart failure.
Advertisement

Investigation of the regenerative process through live imaging and molecular studies revealed how this happens. The cardiomyocytes "dedifferentiate," that is, they revert to an earlier form, something between an embryonic and an adult cell, which can then divide and differentiate into new heart cells. In other words, the ERBB2 took the cells back a step to an earlier, embryonic form; and then stopping its activity promoted the regeneration process.

Researcher Gabriele D'Uva added that they have shown that it can induce cardiac regeneration on its own, but understanding the roles of the other proteins in the chain may present us with new drug targets for treating heart disease.

Tzahor points out that much more research will be required to see if this principle could be applied to the human heart, but the findings are proof that it may be possible.

This research appears in Nature Cell Biology.

Source: ANI
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Can Adjusting Fatty Acid Intake Improve Mood in Bipolar Disorder Patients?
Insulin Resistance Doubles the Risk of Major Depressive Disorder
Emotional Healing
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Surgical Treatment Heart Healthy Heart Statins Mitral Valve Prolapse Aortic Valve Stenosis Pericarditis 

Recommended Reading
Patch Clamp Combined With Atomic Force Microscope Technology to Study Beating Heart Cells
A team of scientists has combined a patch clamp with what is essentially an atomic force microscope ...
Researchers Illuminate Key Structure in Heart Cells
Researchers at Brandeis University have unlocked a controversial structure in heart cells ......
Skin Cells Now Transformed into Beating Heart Cells!
A new method has been devised by an Indian origin researcher which allows complete reprogramming of ...
Scientists Transforms Skin Cells into Beating Heart Cells
The power of regenerative medicine seems to have turned science fiction into scientific reality - .....
Aortic Valve Stenosis
Aortic valve Stenosis is an abnormal narrowing of the c valve. Symptoms include angina, and that of ...
Mitral Valve Prolapse
Mitral Valve Prolapse is a relatively common condition and causes leakage of blood through the valve...
Pericarditis
Pericarditis occurs when the pericardium gets inflamed. Pericarditis is characterized by severe ches...
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use