Reason Behind Sleep-Disordered Breathing And Cardiovascular Disease Explained

Researchers have long known that sleep-disordered breathing is associated with cardiovascular disease (CVD), but had no clue as to why.

Although the link between sleep-disordered breathing and cardiovascular disease (CVD) is known to researchers, the reason has long stumped them. Now a possible link has been established.

Researcher Reena Mehra, assistant professor of medicine at the Case Western Reserve School of Medicine in Cleveland, Ohio, and colleagues examined plasminogen activator inhibitor-1 (PAI-1), fibrinogen and D-dimer, relative to the severity of SDB as defined by the apnea/hypopnea index (AHI) in 537 subjects.

Risk and Consequences of Sleep-Disordered Breathing Increase With Obesity
New research indicates that overweight individuals are not just at greater risk of having sleep-disordered-breathing (SDB), they are also likely to suffer greater consequences.

They found that individuals with even modest levels of SDB (which describes a large proportion of the adult population) may have an enhanced pro-thrombotic biochemical profile, increasing their CVD risk.

Increased morning PAI-1 remained significantly associated with SDB severity in those with mild to moderate SDB even after taking into account evening PAI-1, suggesting that morning may be a reflection of overnight SDB-related physiologic stress, and indicating that PAI-1 may be a good biomarker for assessing SDB stress.

"In summary, these data suggest that, at low to modest levels of SDB, incremental increases in AHI are associated with increases in levels of two pro-thrombotic biomarkers associated with CVD. Future directions include exploring whether treatment of even mild to moderate levels of SDB improves biomarkers of thrombosis, and performing further work to understand the specific pathways and pathobiology of SDB-related increased risk of thrombosis," said Mehra.

Cardiac Arrhythmias Often Are Accompanied By Sleep-Disordered Breathing
Cardiac arrhythmias are often accompanied by sleep-disordered breathing, say German researchers.

John Heffner, M.D., past president of the American Thoracic Society, commented, "This study joins so many others that paint a consistent picture of sleep as a fundamentally important physiologic process for health that can negatively impact multiple organ systems when disordered breathing occurs."

The study appears online ahead of the print edition of the American Journal of Respiratory and Critical Care Medicine on the American Thoracic Society's Web site.

Sleep-disordered Breathing Disproportionately Affects Obese, African-American Kids
A new study has revealed that sleep-disordered breathing (SDB), which can include various sleep behaviours ranging in severity from snoring to obstructive sleep apnea

Source-ANI

Prevalence of Self-reported Snoring, Sleep-disordered Breathing in Military
A previous survey of approximately 5,000 United Kingdom residents found that 48 percent of men and 34 percent of women reported habitual or regular snoring.