Removing a discrete population of cells in the cervix, a novel approach to prevent cervical cancer, has been described in a study published online in the International Journal of Cancer earlier this month. The procedure is based on findings showing successful reduction in the risk of cervical cancer after removal of a discrete population of cells in the cervix.
The findings come from a study that looked at squamocolumnar junction cells, or SCJ cells. These cells reside in the cervical canal and have been implicated as the origins of cervical cancer. A research team co-led by Christopher Crum, MD, director, Brigham and Women's Hospital (BWH) Women's and Perinatal Pathology, demonstrated that removal of SCJ cells resulted in a markedly lower risk of cervical intraepithelial neoplasia—a non-cancerous, abnormal growth of cells on the surface of the cervix that may progress to cervical cancer.
Cervical Cancer - Incidence
Cervical cancer is the second most common cancer among women and is the primary cause of cancer-related deaths in developing countries
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One hundred and thirty-one women with cervical intraepithelial neoplasia were treated with a loop electrosurgical excision procedure to remove the SCJ cells. During the follow-up period (of up to four years), 16 recurrences were identified. Four were identified at the first follow-up visit, and determined to be residual disease, meaning they were not removed in the initial procedure. Twelve manifested after the first postoperative visit and all were in the ectocervix or in mature metaplastic epithelium. All of the 12 delayed recurrences were cervical intraepithelial neoplasias and did not have SCJ cells.
"We have always suspected that most recurrences following apparently successful therapy do not develop in the same location as the original precancer, which was at the squamocolumnar junction," said Crum. "Moreover, studies in the literature have shown that the risk of a significant precancer following successful removal is quite low. Our study is in sync with these observations and suggests that removing SCJ cells might have a significant impact in reducing the risk of cervical cancer."
![Pap or HPV: Best Test for Cervical Cancer?]( "Pap or HPV: Best Test for Cervical Cancer?")
Pap tests or HPV or both, is the question when it comes to testing for cervical cancer.
Crum emphasizes that eliminating SCJ cells does not prevent cervical intraepithelial neoplasias nor does it prevent human papilloma virus (HPV) infection—which can lead to cervical cancer. But what is significant about the findings, according to the researchers, is that removal of SCJ cells seems to alter recurrence patterns, presumably by removing the population that is most vulnerable to development of the more dangerous precancers.
"This is a concept that is in great need of a controlled clinical trial aimed at prevention rather than treatment," said Crum. "It would give us important insights into whether preemptive removal of the SCJ region would have the desired effect."
An accompanying editorial, by Silvia Franceschi, MD, International Agency for Research on Cancer, suggests continuation of the work by "careful evaluation of the impact of prophylactic ablation in the framework of large screening programmes."
Source: Eurekalert
Pap or HPV: Best Test for Cervical Cancer?
Pap tests or HPV or both, is the question when it comes to testing for cervical cancer.
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Crum emphasizes that eliminating SCJ cells does not prevent cervical intraepithelial neoplasias nor does it prevent human papilloma virus (HPV) infection—which can lead to cervical cancer. But what is significant about the findings, according to the researchers, is that removal of SCJ cells seems to alter recurrence patterns, presumably by removing the population that is most vulnerable to development of the more dangerous precancers.
"This is a concept that is in great need of a controlled clinical trial aimed at prevention rather than treatment," said Crum. "It would give us important insights into whether preemptive removal of the SCJ region would have the desired effect."
An accompanying editorial, by Silvia Franceschi, MD, International Agency for Research on Cancer, suggests continuation of the work by "careful evaluation of the impact of prophylactic ablation in the framework of large screening programmes."
Source: Eurekalert
Cost Effectiveness of HPV Primary Screening Vs. Cytology Screening for Cervical Cancer in European Countries
Which form of primary screening for cervical cancer should you opt for according to cost effectiveness and your age? Find out from this report.
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 Quiz on Cervical CancerCervical cancer remains a common cancer in women of the developing world despite a test available for early diagnosis and a vaccine to prevent it. Here's a quiz to test your knowledge on cervical cancer. | Advertisement
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