About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Post-Breastfeeding Milk-Producing Cells are Cannibalized by Other Cells

by Dr. Trupti Shirole on October 14, 2016 at 10:50 PM
Font : A-A+

 Post-Breastfeeding Milk-Producing Cells are Cannibalized by Other Cells

During the lactation process, women produce vast quantities of milk for their babies - up to nearly a liter per day. To do this breasts change dramatically during pregnancy, developing the tissue so that cells can make lots of milk. But when weaning finishes, the breasts need to be remodeled so that they can return to a non-pregnant form.

The human body can usually cope with the limited amount of detritus created from normal cellular lifecycles through the deployment of immune cells to remove the material. But just how it manages to eradicate the large amounts of dead or redundant mammary cells, and left over milk, following breastfeeding without triggering inflammation due to the quantities of immune cells which would be needed, was not fully known.

Advertisement


Soon after lactation, many of the milk-making cells are killed off, in a process called 'apoptosis'. It had been thought that they were then removed through phagocytosis - flushing away the redundant cells by immune cells.

A ground-breaking study into the changes that occur in a woman's breast, from growing into one that provides milk for a new-born, and then back to its normal state, has discovered that milk-producing cells are, in effect, cannibalized by other cells following the period of breastfeeding. However Nasreen Akhtar, the scientist who carried out this study and who is now a Fellow at the University of Sheffield, and her supervisor Charles Streuli, Professor of Cell Biology at The University of Manchester, were intrigued why there was no significant inflammation, pain and tissue damage associated with phagocytosis on such a big scale.
Advertisement

Dr Akhtar said, "Immune-cell phagocytosis might be extremely painful and damaging. So we thought something else must be standing in for the immune cells. What we didn't expect to find was a molecular switch that turned milk-secreting cells into cannibalistic cell eaters. We discovered that these cells were now able to eat or otherwise remove vast quantities of redundant milk-producing cells."

It turned out that a protein called Rac1 is central for the cellular switch. Dr Akhtar found that Rac1 is vital for milk production as well as for the tissue remodelling that occurs after lactation. Moreover, Rac1 also triggers the 'part-time' phagocytic activity that is carried out by the breast epithelial cells. Indeed, Rac1 was needed for clearing post-lactating dead cells and residual milk, helping to reshape the breast back to non-pregnancy.

The study, reported in the journal Developmental Cell, was one of the first to look at how the breast remodels back to its 'normal' state after babies have stopped suckling, revealing a central requirement for the Rac1 signalling protein.

There may also be a role for Rac1 in breast cancer. "Although we cannot be certain at this point, Rac1 may be crucial for breast cancer development. We are studying this process, as it could provide new opportunities for treating the disease," Professor Streuli said.

"And in the future, there may be completely new ways to treat breast cancer - if normal breast cells can eat their slightly altered neighbors, could we find a way to get healthy cells to consume and destroy all the cancer cells?"

The research was reported in a publication 'Rac1 controls both the secretory function of mammary glands and its remodeling for successive gestations' in the journal Developmental Cell; the paper can be found here.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
Test Your Knowledge About Chromosomes?
View all
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Surgical Treatment 

Most Popular on Medindia

Selfie Addiction Calculator Post-Nasal Drip Vent Forte (Theophylline) Accident and Trauma Care Drug - Food Interactions Drug Side Effects Calculator Blood Pressure Calculator Hearing Loss Calculator Sanatogen Calculate Ideal Weight for Infants
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Post-Breastfeeding Milk-Producing Cells are Cannibalized by Other Cells Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests