Poliovirus can be completely eradicated with the help of a newly developed vaccine. A novel one-shot nanoparticle vaccine is the one that delivers multiple doses and prevents paralysis.

"Having a one-shot vaccine that can elicit full protection could be very valuable in being able to achieve eradication," said Ana Jaklenec, a research scientist at MIT's Koch Institute for Integrative Cancer Research in Cambridge, US.
"Children in some of these hard-to-reach developing world locations tend to not get the full series of shots necessary for protection. The goal is to ensure that everyone globally is immunized," Jaklenec added, in a paper appearing in the journal Proceedings of the National Academy of Sciences.
To create a single-injection vaccine, the team encapsulated the inactivated polio vaccine in a biodegradable polymer known as PLGA.
This polymer can be designed to degrade after a certain period of time, allowing the researchers to control when the vaccine is released.
The researchers designed particles that would deliver an initial burst at the time of injection, followed by a second release about 25 days later.
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Furthermore, the researchers said that they could design vaccines that deliver more than two doses, each a month apart and hope to soon be able to test the vaccines in clinical trials.
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Source-IANS