Anti-aging creams are loaded with plant extracts and one such skin care ingredient has been newly identified, which tends to mimic the life-extending effect of a starvation diet, revealed a new study.Using complex genetic data analysis and testing, scientists have shown for the first time that allantoin, which is found in botanical extracts of the comfrey plant and is an ingredient of many anti-ageing creams, can mimic the effect of calorie restriction and increase lifespan in worms by more than 20 percent. Calorie restriction — a reduction in calorie intake without malnutrition, has been found to slow down the ageing process in several animal models from worms to mammals, and developing drugs that can reproduce this effect, without the side effects, could have widespread human applications. ‘Allantoin, a common ingredient in skin creams can mimic the effect of calorie restriction and increase lifespan by slowing down the aging process. ’ "Calorie restriction has been shown to have health benefits in humans and, while more work is necessary, our findings could potentially result in human therapies for age-related diseases," said study lead author Joao Pedro de Magalhaes from University of Liverpool in Britain.To identify potential calorie restriction mimetic compounds, the team made use of existing molecular signatures from human cells and treated with a variety of small-molecule drugs.The researchers found that worms treated with allantoin, rapamycin, trichostatin A and LY-294002 not only lived longer, but also stayed healthier. Molecular analysis of allantoin suggests it acts by a different mechanism from rapamycin, a well-known longevity drug."Testing anti-aging interventions in humans is not practical, so developing computational methods to predict longevity drugs is of great use," Shaun Calvert from University of Liverpool noted. The study was published in the journal Aging Cell.Source: IANS << Pregnant Deaf Woman Hears Baby’s Heartbeat for the First Tim... Prostate Cancer Discovery Could Lead To Better Treatments >> Recommended Reading New Study Supports Life-extending Benefits of Red Wine, Reopens Hope for Anti-aging Pill The new finding renews hope for antiaging pill, shows for the first time that the metabolic benefits of the red wine ingredient resveratrol evaporate in mice that lack the famed longevity gene SIRT1. READ MORE Anti Aging Hormone to Help You Live Longer If You are 'rich' Enough! A hormone called DHEAS makes you live longer - but only if you are 'wealthy' enough, if a new study is to be believed. READ MORE Calorie Restriction may be the Secret to Longevity Certain animal studies conducted on mice and monkeys have shown the benefits of a low-calorie and nutrient-rich diet in extending life expectancy. READ MORE Computer Algorithm may Help Detect Ageing Genes to be Turned Off Scientists have now developed a new computer algorithm that may help predict which genes should be turned off to create an anti-ageing effect similar to calorie restriction READ MORE Ageing and Sleep Sleep is a barometer of good health in the elderly. Sleep problems in the elderly are controlled by various external and internal factors. READ MORE Boils / Skin Abscess Encyclopedia section of medindia gives general info about Boils / Skin Abscess READ MORE Hives Hives or Urticaria are allergic skin reaction that appear suddenly in clusters or as single bumps on the skin surface and can be itchy. READ MORE Lifestyle Modification: No Big Deal! Simple and practically possible lifestyle changes can make a huge difference in improving our health status without actually putting much effort. READ MORE Low Calorie Diet Low calorie meals or diet include foods that are high on nutritional content and yet have fewer calories. Updated information about low calorie diet or low calorie foods and its health benefits. READ MORE Pemphigus Pemphigus is a rare group of autoimmune diseases that affect the skin and mucous membranes causing blisters and sores that fail to heal. READ MORE Pityriasis Rosea Pityriasis rosea is a common skin disease that is not contagious. It manifests as oval-shaped, pink or red rash READ MORE Scleroderma Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as thick, dry, fibrous skin. Scleroderma/CREST syndrome is classified as rheumatic and connective tissue disease. READ MORE Why Do We Eat - Nutrition Facts The importance of eating food and the physiological, psychological and social functions of food. READ MORE Most Popular on Medindia Blood Donation - Recipients A-Z Drug Brands in India Daily Calorie Requirements More News on: Low Calorie DietBoils / Skin AbscessWhy Do We Eat - Nutrition FactsDiet Lifestyle and Heart DiseaseAgeing and SleepPityriasis roseaPemphigusHivesSclerodermaLifestyle Modification: No Big Deal!