The study conducted by Washington University School of Medicine researchers reveals that PET 'can reliably identify patients who have a poorer prognosis'.
"We've seen that among patients with the same stage of cervical cancer, there will be some patients who don't respond to treatment as well as others," said lead author Elizabeth A. Kidd, M.D., a Barnes-Jewish Hospital resident in Washington University's Department of Radiation Oncology.
"Our study suggests that PET (positron emission tomography) can reliably identify patients who have a poorer prognosis." A. Kidd added.
The researchers used FDG-PET, a widely available three-dimensional scanning technique. FDG-PET measures how rapidly tumours take up a radio labelled glucose tracer.
(FDG) — high uptake results in a stronger or brighter signal in the scan. The researchers found that the higher the standard uptake value (SUV) for FDG in the primary tumour, the greater the recurrence rate and the lower the survival rate of patients.
"FDG-PET is the most commonly used PET scan. It's standard for patients to have this type of scan once diagnosed with cervical cancer. Oncologists use it to see the extent of the primary tumour and to look for tumours that have spread beyond the pelvis. But this study shows that the SUV obtained from FDG-PET can also tell physicians how well a patient will respond to treatment and should be part of the evaluation process," Kidd explained.
A high SUV at diagnosis could signal that a patient should be followed more closely than usual after treatment to catch recurrences earlier, according to Kidd. She also indicates that although the results suggest that patients with high SUV tumours may need more aggressive treatments, further clinical studies will be necessary to determine the best therapy in such cases.
In the current study, 287 patients with cervical cancer were treated with surgery, chemotherapy or radiation therapy following standard treatment protocols. At the time of diagnosis, the SUV of their primary tumour was obtained. Their cancers were also staged under standard guidelines, which rely largely on tumour size and involvement with surrounding tissues. The patients' cancers ranged from early (stage 1A2) to highly advanced (stage 4B).
The researchers showed that patients who had a high tumour SUV were more likely to have aggressive disease. They were likely to have cancerous cells in their lymph nodes, persistent disease after initial treatment, recurrence of disease in the pelvis and lower survival rates. They also found that tumour SUV did not depend on the tumour stage or volume — large tumours could have a relatively low SUV, and small tumours could have a high SUV.
The findings suggest that SUV is a more sensitive indicator of tumour aggressiveness than standard staging protocols. The study also demonstrated that SUV was better at predicting overall survival than the type of tumour or lymph node involvement, factors suspected to affect prognosis.
The patients were found to fall into three distinct risk groups. Those with the lowest SUV had a survival rate of 95 percent at five years, those in the middle SUV range had a 70 percent five-year survival rate, and those in the highest SUV range had a 44 percent five-year survival rate.
Because high SUV indicates that tumours take up glucose rapidly, the measurement may point to an important biological difference in these more aggressive cancers.
"We're interested in finding out what causes that difference," Kidd says. "That could eventually lead to new methods for treating patients whose tumours have a high SUV."
The study is published in the upcoming issue of the journal Cancer.