Type-O blood is known as the universal donor and can be given to patients of all blood types. With this enzyme, Jayachandran Kizhakkedathu from the University of British Columbia and colleagues were able to remove the wide majority of the antigens in Type-A and B blood.
"We produced a mutant enzyme that is very efficient at cutting off the sugars in A and B blood, and is much more proficient at removing the subtypes of the A-antigen that the parent enzyme struggles with," said lead author of the study David Kwan from the University of British Columbia in Canada.
In just five generations, the enzyme became 170 times more effective.
While the researchers were able to remove the wide majority of the antigens in Type-A and B blood, before it can be used in clinical settings, the enzyme used would need to remove all of the antigens.
The immune system is highly sensitive to blood groups and even small amounts of residual antigens could trigger an immune response.
The findings appeared in Journal of the American Chemical Society.
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