About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Oral Bacteriome and Mycobiome, Markers for Tongue Cancer

by Anjali Aryamvally on December 20, 2017 at 11:43 AM
Font : A-A+

Oral Bacteriome and Mycobiome, Markers for Tongue Cancer

Oral tongue cancer or squamous cell carcinoma of the tongue is an aggressive form of cancer that generally affects older people. These patients often find it difficult to eat, swallow food, or speak. Reasons for its poor prognosis include late detection, before pain usually starts and only when physical symptoms such as lesions are present, and a propensity for spreading to other sites in the body.

But in a potential harbinger of hope for arriving at an earlier diagnosis and treatment, in a new study published in Oncotarget, a research team from Case Western Reserve University School of Medicine, Cleveland Clinic, and University Hospitals Cleveland Medical Center has found that bacterial diversity and richness, and fungal richness, are significantly reduced in tumor tissue compared to their matched non-tumor tissues. This raises the prospect that certain bacteria and fungi, in sufficient amounts and in possibly interactive ways, may play a part in the development of oral tongue cancer.

Advertisement


"Our findings mean that it may be possible to perform precautionary testing in patients at high-risk for oral tongue cancer," said the study's co-senior author Mahmoud A. Ghannoum, PhD, professor in the Department of Dermatology at Case Western Reserve School of Medicine and University Hospitals Cleveland Medical Center. "If the patterns that we found are present in people who are not yet showing signs of lesions, we could begin treatment early, offering the possibility of better patient outcomes."

Oral tongue cancer

Oral tongue cancer, which arises in the anterior two-thirds [front] of the tongue, has been rapidly increasing and is now the second most common malignancy in the oral cavity. While human papillomavirus causes nearly ninety percent of base-of-tongue tumors [back], HPV is rarely found (only 2.3 percent) in oral tongue cancer. The causes of oral tongue cancer are unclear, but genetic mutations probably play a role, while smoking and chewing of tobacco, alcohol use, and poor dental hygiene are correlated with the development of this type of cancer.
Advertisement

"Poor oral hygiene has long been associated with oral cancers, suggesting that oral bacteriome (bacterial community) and mycobiome (fungal community) could play a role," said co-senior author Charis Eng, MD, PhD, professor and vice chairman of the Department of Genetics and Genome Sciences at Case Western Reserve School of Medicine and Hardis Chair of the Genomic Medicine Institute at the Cleveland Clinic.

While the bacteriome is increasingly recognized as playing an active role in health, the role of the mycobiome has been much less studied, and never before in the case of oral tongue cancer. In the new study, the researchers extracted tissue DNA from 39 paired tumor and adjacent normal tissues from patients with the cancer. Analyses showed that Firmicutes was the most abundant bacterial phylum, and was significantly increased in tumor compared to non-tumor tissue, 48 percent vs. 40 percent, respectively. In total, the abundance of 22 bacterial and seven fungal genera [types] was significantly different between the tumor and adjacent normal tissue, including Streptococcus, which was significantly increased in the tumor group (34 percent vs. 22 percent in normal tissue.)

"Studies are starting to emerge demonstrating interactions between bacteria and fungi in the formation of disease," said Ghannoum. "Thus, additional research is needed aimed at understanding how these two communities influence or are influenced in disease settings such as oral tongue cancer."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
Spirituality and Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Tongue Abnormalities Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Dental Check-Up Tongue Tie Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Learn What Your Tongue Says About Your General Health 

Recommended Reading
Squamous-cell Tongue Cancer Cases Increase in Young, White Women
111% increase in cases of squamous-cell tongue cancer among young white women while there has been ....
Surgery Beats Chemotherapy for Tongue Cancer: Study
New study conducted by researchers reveals that tongue cancer patients who first underwent surgery ....
New Dental Material Found to Fight Bacteria, Prevent Plaque
New dental composite material resists biofilm growth its low dose of antimicrobial agent kills only ...
Bacteria in Mouth Increase Risk of Esophageal Cancer
Certain bacteria types in the mouth are associated with periodontal disease, which can lead to an .....
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Dental Check-Up
It is commonly recommended that you visit the dentist twice a year to clean your teeth and gums and ...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Learn What Your Tongue Says About Your General Health
The tongue aids in chewing, talking and oral cleansing. However, it may also be an indicator of many...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...
Tongue Abnormalities
Tongue is the only muscle that is attached to only one end. The abnormalities of the tongue include ...
Tongue Tie
Tongue Tie or Ankyloglossia is a congenital disorder arising from the total or partial fusion of the...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use