Obesity-Induced Kidney Damage may be Combated by Grape Seed and Skin Extract

A new study has revealed that grape seed and skin extract (GSSE) could be a weapon in the fight against kidney disease caused by high-fat diets.

GSSE is known to contain powerful antioxidants. The study is the first to make a link between GSSEs and high-fat-diet-induced renal disease.

Mediterranean Diet - Benefits - Components - Olive Oil - FAQs
Mediterranean diet has long been considered one of the healthiest diets on the planet. This diet plan discourages the use of saturated fats and hydrogenated oils while cooking meals.

The researchers examined the effect of GSSE processed from a grape cultivar ('Carignan') of Vitis vinifera from northern Tunisia on rats.

Rats were fed a high-fat diet that induced a low-grade reno-lipotoxicity, that is, kidney damage associated with lipids. This was characterized by elevations in plasma urea and protein in the urine.

The researchers found increased deposits of triglycerides (TG) (especially saturated fatty acids), increased signs of oxidative stress and depleted copper levels in the kidneys. There was also histological evidence of disturbance in the kidney structure.

Macrobiotic Diet - Yin and Yang Food - Advantages - Disadvantages - Theories
Macrobiotics is an Oriental theory that lays down guidelines for promoting well-being and longevity through systematic diet consisting mainly of whole grains and beans.

When the animals received GSSE at 500 mg/kg bw (which corresponds to 35g/day for a 70 kg human adult) along with the high-fat diet there was a partial reversal of the TG deposition as well as the histological damage.

The researchers suggested that polyphenols including resveratrol are likely the components in GSSE responsible for the positive effects. Furthermore the GSSE prevented the oxidative stress and copper depletion.

Acid Base Dietary Balance and its Influence on Our Health and Wellbeing
Our lifestyles and eating habits can lead to acid build up and push the body to an unhealthy state. Understanding alkaline body state is important for our long term health.

"In our research, obesity-induced leaky kidney and proteinuria are shown to be prevented by GSSE, which suggests the use of GSSE as a preventive nutriceutical for high-risk patients," said co-author Kamel Charradi, a researcher with the Laboratory of Bioactive Substance at the Center of Biotechnology of Borj-Cedria (CBBC) in Tunisia.

This research group has previously published work showing the benefits of GSSE in combating obesity, heart dysfunction, brain lipotoxicity and kidney cancer.

Cholesterol - The Enigma Chemical - Myths - Diet - Functions
The word 'Cholesterol' rings danger bells as soon as it is mentioned. This important chemical is important for the normal metabolism of the body and is dangerous only if present in excess.

The study is published in the journal Applied Physiology, Nutrition, and Metabolism.

Source-ANI