About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Novel Study Finds a Way to Prevent Melanoma Metastasis

by Megha Ramaviswanathan on February 27, 2018 at 11:29 AM
Font : A-A+

Novel Study Finds a Way to Prevent Melanoma Metastasis

Drugs used to treat leukemia can also be used to prevent melanoma metastasis, according to a new study by scientists at University of Kentucky Markey Cancer Center.

The study published in Science Signaling showed new evidence linking the activation of ABL kinases - cancer-promoting genes - to the secretion of pro-metastatic cathepsins in melanoma. Cathepsins are enzymes that degrade proteins and are highly expressed in cancer cells, resulting in their release into the environment between the cells. These enzymes "chew up" the fibrous matrix around tumors, which allows them to get into the blood stream and lymphatic system and spread around the body.

Advertisement


Their work showed that ABL kinases induce cathepsin expression and secretion by increasing the activity of key transcription factors that upregulate numerous proteins involved in metastasis. Transcription factors bind to the regulatory part of genes and induce their expression. This study is the first to demonstrate that ABL kinases not only increase the abundance of the transcription factors, but also regulate the ability of these transcription factors to bind to the promoters and induce gene expression.

Lastly, the scientists found that ABL kinases inhibitors already approved by the Food & Drug Administration (FDA) for treating leukemia also prevented metastasis induced by secreted cathepsins in animal models of metastatic melanoma.
Advertisement

"These data have important therapeutic implications, as drugs that inhibit ABL kinases have been used for decades to treat leukemia with few side effects," said Rakshamani Tripathi, postdoctoral scholar in the UK Department of Pharmacology and Nutritional Sciences and lead author on the study. "Repurposing these drugs may represent a new strategy for targeting cathepsins and may be an effective approach for treating metastatic melanoma patients."

The number of new cases of melanoma, as well as melanoma death rates, have increased steadily for the past 30 years in the United States. Metastasis to distant organ sites such as the lung, liver, brain and bone is the major cause of melanoma-related deaths. Despite new advances in metastatic melanoma treatment, the 5-year survival rate is only 15 to 20 percent.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Skin Cancer Ultra-Violet Radiation Amyotrophic Lateral Sclerosis (ALS) Melanoma Acute Coronary Syndrome 

Recommended Reading
Leukemia
Encyclopedia section of medindia gives general information about Leukemia...
New Cancer-Causing Pathway Identified That Causes Leukemia
The DNA of immature blood cells, mainly white cells, becomes damaged in some way. This abnormality ....
Possibility Of Halting Melanoma Metastasis With The Help Of Research Breakthrough
Scientists have eliminated metastasis,in melanoma by inhibiting a protein known as melanoma ......
Protein Key to Melanoma Metastasis Identified
P-Rex1 - key protein behind metastasis of melanoma has been identified by UNC Lineberger ......
Acute Coronary Syndrome
Acute coronary syndrome (ACS) is a sudden, acute life-threatening condition caused by a dramatic red...
Amyotrophic Lateral Sclerosis (ALS)
Find out more about the degenerative disease- Amyotrophic lateral sclerosis....
Melanoma
Melanoma is a dangerous form of skin cancer caused largely due to exposure to the sun’s damaging UV ...
Skin Cancer
Skin cancer is an abnormal growth of skin cells. It can develop due to a continuous exposure to sun ...
Ultra-Violet Radiation
Ultraviolet radiations are electromagnetic radiations with wavelengths shorter than the shortest wav...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use