Medindia
Advertisement

Next-gen Therapeutics Show Promise for Alzheimer’s Disease Treatment

by Colleen Fleiss on December 9, 2018 at 1:02 AM

Next-gen Therapeutics Show Promise for Alzheimer’s Disease Treatment
A new scientific strategy was found to explore the therapeutic targets based on the biology of aging -- gaining ground as an effective approach to prevent and treat Alzheimer's disease, stated study published in Neurology.

A comprehensive review of the clinical trial landscape, including current agents being studied for the prevention and treatment of Alzheimer's disease (and other dementias), points to the need to develop and test drugs based on an understanding of the multiple effects of aging on the brain.
Advertisement


"Alzheimer's is a complex disease with many different factors that contribute to its onset and progression," says Dr. Howard Fillit, founding executive director and chief science officer of the Alzheimer's Drug Discovery Foundation (ADDF), senior author of the review paper. "Decades of research have revealed common processes that are relevant to understanding why the aging brain is vulnerable to Alzheimer's disease. New therapeutics for Alzheimer's disease will come from this understanding of the effects of aging on the brain."

The only approved medications for Alzheimer's disease relieve some symptoms but do not halt disease progression. New therapies that prevent, slow, or stop the disease are urgently needed to fight the growing Alzheimer's disease burden in the United States and around the world. And, aging biology provides numerous novel targets for new drug development for Alzheimer's disease, notes Dr. Fillit.
Advertisement

"Our success in fighting Alzheimer's disease will likely come from combination therapy - finding drugs that have positive effects on the malfunctions that happen as people age," says Dr. Fillit. "Combination therapies are the standard of care for other major diseases of aging, such as heart disease, cancer, and hypertension, and will likely be necessary in treating Alzheimer's disease and other dementias."

Increasing age is the leading risk factor for Alzheimer's disease, a progressive neurodegenerative disease that affects 5 million people in the United States and about 50 million globally. With a growing aging population, the Centers for Disease Control and Prevention projects the burden of Alzheimer's disease will nearly triple to 14 million people by 2060. With aging, many biological processes go awry that have also been implicated in Alzheimer's disease. For example, as people age, they are more likely to have chronic systemic inflammation and neuroinflammation, which is associated with poorer cognitive function. Other aging malfunctions include impaired clearance of toxic misfolded proteins, mitochondrial and metabolic dysfunctions (associated with diabetes), vascular problems, epigenetic changes (changes in gene regulation without alterations in the DNA sequence), and loss of synapses (points of communication between neurons).

Later-phase (phase 3) trials are dominated by drugs targeting beta-amyloid and tau, the classic pathological hallmarks of Alzheimer's disease (of phase 3 trials, 52% are targeting amyloid or tau), but other strategies are gaining ground and are in phase 1 or 2 trials, according to the review paper.

Although therapeutic attempts to remove or decrease the production of beta-amyloid have been largely unsuccessful in altering the disease course of Alzheimer's disease, says Dr. Fillit, researchers learned important information from those clinical trials even if they didn't immediately result in treatments for Alzheimer's patients. And recent clinical trials suggest that problems with clearance of beta-amyloid may yet prove fruitful.

"It is currently not known if these classic pathologies (amyloid and tau) represent valid drug targets and if these targets alone are sufficient to treat Alzheimer's disease," says Dr. Fillit. "Targeting the common biological processes of aging may be an effective approach to developing therapies to prevent or delay age-related diseases, such as Alzheimer's."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
Lower Respiratory Tract Infections Linked to Obstructive Sleep Apnea in Children
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Common Lifestyle Habits that Cause Diseases Dementia 

Recommended Reading
Alzheimers Disease
Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and ......
Quiz On Alzheimer’s Disease
Alzheimer's disease (AD) is the most common form of dementia. Participate in this quiz to find out ....
Ten Super Foods to Boost your Brain Power
Enhance your brain health by adding super foods to your daily diet. Here are 10 of them....
Alzheimer's Risk Assessment Calculator
Alzheimer's Risk Assessment Calculator is a tool to measure the level of Alzheimer's disease. It .....
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Dementia
Dementia has become a very big concern as we have an aging population across the world. Dementia is ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use