About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Newly Discovered Molecule Could Harbour Motor Neurone Disease Cure

by VR Sreeraman on November 19, 2008 at 11:17 AM
Font : A-A+

 Newly Discovered Molecule Could Harbour Motor Neurone Disease Cure

Scientists have discovered a molecule that could be the key to understanding the cause of neurodegenerative diseases such as motor neurone disease (MND).

Lead researcher Professor Patricia Salinas, from University College London along with Dr Simon Hughes, from King's College London has identified a signalling molecule called Wnt3 that plays a crucial role in creating the connections, or synapses, between nerves and the muscles they control.

Advertisement

"For decades we have been studying how nerves communicate with their target muscles and we know that in diseases like MND the sites of contact between nerves and muscles become weak," said Salinas.

The new find offers a new possibility for developing drugs to treat MND and other neurodegenerative diseases.

Wnt3 works along with another molecule called Agrin, which coordinates construction of the synapse and organises the elements that make up the connection.
Advertisement

The team looked at the Wnt signals in chickens, mice and in cells it was shown to enhance the effectiveness of Agrin.

"Without properly formed synapses the muscle cannot receive the nerve signal that tells it to contract and hence we see the muscle weakness that is classic in MND," said Salinas.

"If we can build up a thorough picture to show how synapses are normally formed between nerves and muscles we can start to look for any elements that aren't working properly in people with MND.

"This might also lead to strategies for nerve repair after an injury.

"Now that we understand the role Wnt plays we can begin to explore any role it plays in MND and whether it could be a good target for treating this type of neurodegenerative disease," she added.

The study is published in the Proceedings of the National Academy of Sciences.

Source: ANI
LIN
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Fermented Skin Care
Television Binge-Watching May Boost the Risk of Deadly Blood Clots
Western Diet may Augment the Risk of Autoimmune Diseases
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.


Recommended Reading
Parkinsons Disease
Parkinson's disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Parkinson's Disease - Surgical Treatment - Animation
Slide animation on surgery for Parkinson disease. Surgery is only indicated where drugs fail to ......
Scientists Identify Novel Therapeutic Compounds That can Prevent Neurodegeneration
American researchers have identified a class of compounds that can prevent degeneration of neurons, ...
Researchers Identify Gene Linked to Lou Gehrig's Disease
Researchers from Canada and France have identified a new gene, called TDP-43, which is responsible ....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)