A new treatment which involves targeting tiny blood vessels inside the kidneys may slow down the progression of an inherited kidney disease that is affecting around 12.5 million individuals worldwide, claims a new research.
Polycystic kidney disease (PKD), the world's most common inherited kidney disease, is a genetic disorder where fluid filled cysts grow in kidneys and destroy normal renal tissue.
Alternate Non-invasive Method To Diagnose Kidney Diseases Using Raman Spectroscopy
Raman Spectroscopy signals help doctors to differentiate between a healthy kidney and a diseased kidney than looking for a specific bio-marker.
Advertisement
"With further testing, treatments that target blood vessels surrounding the kidney cysts, perhaps in combination with currently used drugs, may prove to be beneficial for patients with polycystic kidney disease," said lead researcher David Long from University College London. "If we could target these blood vessels early in the development of the condition it could potentially lead to much better outcomes for patients," co-author of the study Adrian Woolf, professor of pediatric science at the University of Manchester in Britain, said.
Treatment for the condition has traditionally targeted proteins which are thought to play a role in causing the condition and are located in hair-like structures and tissue that line the inside of cysts. These treatments can help alleviate some of the symptoms of PKD but they cannot currently cure the condition.
![Newly Discovered Treatment Using Molecule Inhibitors May Help Rare Kidney Disease]( "Newly Discovered Treatment Using Molecule Inhibitors May Help Rare Kidney Disease")
The precise region of PLA2R where antibodies attack has been found, and also the molecules that block antibodies from binding to PLA2R protein.
By looking at mouse models of both the common and rarer form of the disease, the team noticed that tiny blood vessels surrounding the cysts were altered very early in cyst development.
They therefore treated the mice with a protein called VEGFC, and found that patterns of blood vessels normalized and the function of the kidneys improved.
In the mice with the rare form of the condition, it also led to a modest but significant increase in lifespan.
The study was published in the Journal of the American Society of Nephrology.
Source: IANS
Newly Discovered Treatment Using Molecule Inhibitors May Help Rare Kidney Disease
The precise region of PLA2R where antibodies attack has been found, and also the molecules that block antibodies from binding to PLA2R protein.
Advertisement
By looking at mouse models of both the common and rarer form of the disease, the team noticed that tiny blood vessels surrounding the cysts were altered very early in cyst development.
They therefore treated the mice with a protein called VEGFC, and found that patterns of blood vessels normalized and the function of the kidneys improved.
In the mice with the rare form of the condition, it also led to a modest but significant increase in lifespan.
The study was published in the Journal of the American Society of Nephrology.
Source: IANS
10-Year-Old Boy With Kidney Disease Fulfills His Dream of Becoming Police Chief
The Make A Wish Foundation of India and, the Rajasthan Police helped Girish Sharma fulfill his wish of becoming a police chief.
Advertisement
 10% World Population Has Chronic Kidney DiseaseAround 10% of the world's population suffers from Chronic Kidney Disease (CKD), said a nephrology expert. | Advertisement
|
Advertisement
Recommended Reading
Latest General Health News
In India, youth must be aware of the diseases linked to cigarette smoking and tobacco consumption, causing a form of healthcare emergency.
Direct coastal access may represent a viable route to public health promotion, but the relationships of coastal living are not strongest among lower-income groups.
New research by Tinnitus UK has found that over four million gardeners are putting their hearing capacity at risk this summer without using safety protection.
Mucus plugs could be targeted to help reduce fatalities from chronic obstructive pulmonary disease.
The development of reliable curative therapies for multiple sclerosis could significantly reduce the economic burden of the disease on patients and wider society.