About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Model to Predict Effective Microbiome Therapies for Allergic Diseases

by Adeline Dorcas on April 18, 2018 at 1:25 PM
Font : A-A+

New Model to Predict Effective Microbiome Therapies for Allergic Diseases

A new mathematical model was found to study the effectiveness of microbiome therapies that can manage the immune system and help in the treatment of inflammatory or allergic diseases, in a new study published in eLife.

Until now, it was experimentally intractable to identify the optimal combination of bacteria that would generate the desired anti-inflammatory treatment response. But researchers have now developed a model that predicted the most effective treatment in mice.

Advertisement


Introduction of therapeutically potent bacteria into patients with infections or metabolic diseases is an emerging approach with great promise. But there are two challenges standing in the way of its success. First, the bacteria must be able to set up home alongside the already resident microbes. Second, in the context of autoimmune diseases, they must stimulate a range of immune responses that dampen down unwanted inflammation. This study focused on stimulating one such group of immune cells called regulatory T-cells, or Tregs.

Single bacterial strains are less effective than groups of different strains. But testing the huge number of potential bacterial combinations experimentally simply isn't feasible.
Advertisement

"In previous work, our collaborators and paper co-authors identified 17 different strains of bacteria that can generate the required immune response, but determining the best combinations from these strains would need more than 130,000 independent experiments," explains senior author Professor Vanni Bucci, Assistant Professor at the University of Massachusetts at Dartmouth, USA.

"The goal of this study was to develop a mathematical model to rapidly and systematically select groups of bacteria that would optimally produce the desired immune response."

The team built a model using published and newly generated data showing which bacterial strains were most efficient at colonizing the gut and at stimulating Treg cells in germ-free mice, both individually and together. They then combined this model with another that predicts the growth and expansion of bacterial colonies in mice over time.

This allowed them to determine both the growth of each bacterial strain in the mice, and the extent of each strain's contribution to the increase in Treg immune cells. Based on this, they developed a way of scoring how well groups of bacteria colonize together and stimulate an immune response. They then tested every possible bacterial combination generating a ranked list of bacterial combinations.

To measure the model's accuracy, they tested five different four-strain combinations of bacteria in germ-free mice. They found that the bacterial combinations with the highest scores predicted by the model not only stimulated immune cells more potently, but also colonized more stably the gut - proving the value of including both measures in the model.

"Treatment of immune or inflammatory diseases is not necessarily achieved by targeting a single biological function but will require simultaneous manipulation of multiple processes within the host-immune system," said lead author Dr Richard Stein, Research Associate at the Dana-Farber Cancer Institute, USA.

"To our knowledge, this is the first model that allows for the simultaneous prediction of the dynamics of both the microbiota and the immune response. It can be considered a stepping stone to the development and rational design of microbiome therapies."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Memory Loss - Can it be Recovered?
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Allergy Dealing with Pollen Allergy 

Recommended Reading
Allergy
An allergy is a hypersensitive disorder of immune system. Substances that often cause allergic ......
Gut Microbiome Influences Efficacy of Cancer Immunotherapy
Patients with melanoma treated with anti-PD1 drugs have their disease controlled, if they have a ......
Gut Microbiome Influenced by Genes and the Environment
Gut microbiome influenced by genes and home environment will aid in nurturing the right microbiota ....
Specific Probiotic Combination Helps to Alleviate Allergy-Related Symptoms
Prebiotic combination helps to reduce symptoms of allergy and improve quality of life, if taken ......
Dealing with Pollen Allergy
The plants around you that give you sniffles in your nose at specific time of the year are the sourc...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use