New Method for Assessment of UTI Risk In Women After Pelvic-Floor Surgery

A way to assess the risk for developing a urinary tract infection (UTI) following pelvic-floor surgery, has been identified by the researchers at Loyola University Chicago Stritch School of Medicine.

A way to assess the risk for developing a urinary tract infection (UTI) following pelvic-floor surgery, has been identified by the researchers at Loyola University Chicago Stritch School of Medicine. These findings were reported in the latest issue of PLOS ONE.

Urinary tract infections (UTIs) are the most common type of bacterial infection and have estimated treatment costs exceeding $1 billion a year in the United States. Women who undergo surgery for pelvic-organ prolapse or urinary incontinence are more likely to develop a UTI following the procedure. Clinicians have lacked effective methods to identify, and ultimately treat, specific patients with an increased UTI risk in the past.

Urinary Infection
Bacterial infection of urinary bladder can cause pain and burning sensation while passing urine. Abnormal Vesico-ureteric reflex, due to which the urine goes back to the kidneys from the bladder is also known to cause infection.

This study found that certain urinary bacteria and antimicrobial peptides, which normally help the bladder immune system function, may identify women at increased risk for a UTI following pelvic-floor surgery.

"This information may help us improve UTI prevention and treatment strategies for women down the road," said Katherine Radek, PhD, senior author, assistant professor, Department of Surgery and a member of Loyola's Burn & Shock Trauma Research Institute.

The study explored the relationship between urinary bacteria, antimicrobial peptides and UTI symptom severity in 54 women undergoing pelvic-floor surgery. Study participants completed a questionnaire and provided a catheterized urine specimen obtained under anesthesia on the day of surgery. The urine was analyzed using advanced DNA-based detection methods.

About Phimosis
The term 'Phimosis' derived from the Greek word for 'muzzling' has been widely applied to narrow foreskin.

Thirteen participants (24 percent) had positive urine cultures before surgery. The rest (n = 41, 76 percent) had negative urine cultures before surgery. Of these 54 women, 10 (18.5 percent) developed UTI symptoms after surgery, while four (7 percent) had positive urine cultures after surgery.

Researchers found that the diversity and abundance of specific urinary bacteria and the amount of a specific antimicrobial peptide were different in women who developed a UTI following surgery compared with those who did not: lower risk of postoperatvie UTI correlated with greater bacterial diversity, greater abundance of the Lactobacillus species and higher levels of the antimicrobial peptide β-defensin-1.