About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Insights May Lead to Personalized Medical Therapies for Emerging Food Allergy Disorder

by Adeline Dorcas on May 5, 2018 at 3:41 PM
Font : A-A+

New Insights May Lead to Personalized Medical Therapies for Emerging Food Allergy Disorder

The discovery of three distinct subtypes of eosinophilic esophagitis (EoE), an emerging food allergic disease may provide a framework for developing exact medicines to treat the disorder, reports a new study by a research team at Cincinnati Children's Hospital Medical Center.

The researchers found that each of the three groups, or endotypes (EoEe1, EoEe2, and EoEe3), was associated with different clinical features and molecular pathways.

Advertisement


"Our goal is to provide the type of deep disease understanding and therapeutic decision-making that is now becoming routine in the cancer field," says Marc Rothenberg, MD, Ph.D. director of allergy and immunology at Cincinnati Children's and senior author of the study. "We applied deep molecular profiling of biopsy tissues from patients undergoing endoscopy to evaluate the presence of EoE.

We found that molecular profiling provided an advantage compared with classical microscopic analysis, the traditional approach to looking at biopsy specimens. These findings provide a potential framework for developing distinct predictive medicine and future therapeutic strategies for specific EoE subpopulations."
Advertisement

The study, conducted at research institutions throughout the United States, is published in The Lancet Gastroenterology & Hepatology.

The scientists studied biopsies of 185 children and adults at 10 sites associated with the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). After analyzing various structural and molecular features, they identified endotypes that were consistent across children and adults and were independent of the number of eosinophils in each sample. The three identified endotypes ranged from mild to severe.

Eosinophils are normal cellular components of the blood, but when the body produces too many eosinophils, they can cause a variety of eosinophilic disorders, such as EoE. These are disorders involving chronic inflammation and resulting in tissue damage, often in the gastrointestinal system, including the esophagus.

"We have identified genes that are altered within each of the EoE endotypes, establishing insight into distinct disease mechanisms and allowing us to consider personalized treatment approaches," says Dr. Rothenberg. "This is an important stride forward for the allergy and gastroenterology fields. With emerging new therapies for allergic diseases, including a new class of anti-eosinophil drugs, as well as anti-inflammatory biological agents that block specific component of allergic inflammation, this is good news for patients, as this brings the field one step closer to personalized and precision therapy."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Sensory Processing Disorder (SPD)
First Dose of COVID-19 Vaccines May Improve Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Allergy Why Do We Eat - Nutrition Facts Diet Lifestyle and Heart Disease Celiac Disease Types of Food Allergies Irritable Bowel Syndrome Hunger Fullness and Weight Control Dealing with Pollen Allergy Remedies for Seasonal Allergy Relief Choose The Right Over-the-Counter Drugs for Allergy 

Recommended Reading
Food Allergy Disorder - The Understudied Health Area
Researchers have found that eosinophilic gastritis is a systemic disorder that has high levels of .....
Protein 'calpain 14' Responsible for Damage in Eosinophilic Esophagitis
Controlling the production or activity of protein calpain 14 may prevent the development of ......
High-dose Fluticasone Effective Against Eosinophilic Esophagitis, Says Study
Increased doses of the corticosteroid fluticasone propionate safely and effectively induce ......
Allergy
An allergy is a hypersensitive disorder of immune system. Substances that often cause allergic react...
Celiac Disease
Celiac disease is labeled as a digestive disorder associated with malabsorption as well as an abnorm...
Choose The Right Over-the-Counter Drugs for Allergy
Over-the-counter (OTC) drugs can be bought without a prescription. OTC allergy medications are for t...
Dealing with Pollen Allergy
The plants around you that give you sniffles in your nose at specific time of the year are the sourc...
Hunger Fullness and Weight Control
An erratic way of eating or any metabolic disturbance in the hunger fullness signals is one of the m...
Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) causes recurrent abdominal pain or discomfort and a fluctuating distu...
Remedies for Seasonal Allergy Relief
Understanding the cause and mechanism of seasonal allergy can help in choosing the right treatment. ...
Types of Food Allergies
If you are allergic to certain food items-Watch out for what you eat...
Why Do We Eat - Nutrition Facts
The importance of eating food and the physiological, psychological and social functions of food....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use