After the deletion of PDZK1IP1 gene, colon cancer growth slowed down, suggesting that PDZK1IP1 and its super enhancer could be targets for anti-cancer therapies.
Genetics Behind Colon Cancer Growth
This super enhancer - the largest 1-2 percent of all enhancers in the cell - regulates the gene PDZK1IP1, which was previously not identified as a cancer gene.
Diet to Prevent Colon Cancer - Health Tips - Glossary
Diet and lifestyle play an important role in reducing the risk and delaying the onset of cancer. Incorporating and eliminating certain other foods may reduce the risk of acquiring colon cancer.
Diet and lifestyle play an important role in reducing the risk and delaying the onset of cancer. Incorporating and eliminating certain other foods may reduce the risk of acquiring colon cancer.
‘In the US, colon cancer is the third most prevalent and second most deadly cancer.’
"This cancer is reliant on surgery for treatment, and immunotherapies that have revolutionized the treatment of advanced cancer have only worked for a small subset of colon cancer patients. That's why there's a great need for novel target identification," Zhou added. This study, published in the journal Nature Communication, found that the super enhancer is activated by surrounding inflammation in the tumor microenvironment.
The inflammation allows the cancer cells to survive in an environment they otherwise would not. Inflammatory bowel disease is a known risk for colon cancer; this finding could add to the understanding of the mechanism involved.
Colorectal Cancer Screening
Colorectal screening is done using tests to detect blood in stool, colonoscopy or sigmoidoscopy ordouble contrast barium enema or CT colonography.
Colorectal screening is done using tests to detect blood in stool, colonoscopy or sigmoidoscopy ordouble contrast barium enema or CT colonography.
Quiz on Colon
Are you suffering from a migraine? It is possible that you have an unhealthy bowel. Strange - but true! This quiz is packed with information on the colon. Participate to learn more!
Are you suffering from a migraine? It is possible that you have an unhealthy bowel. Strange - but true! This quiz is packed with information on the colon. Participate to learn more!
Potential Therapeutic Target for Colonic Disorders
Colonic motility disorders, especially problems associated with constipation and diarrhea, are common in adults and children, greatly impacting quality of life.
Colonic motility disorders, especially problems associated with constipation and diarrhea, are common in adults and children, greatly impacting quality of life.
