About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Epigenetic Compounds Show Promise in Patients With Lymphoma

by Colleen Fleiss on March 6, 2018 at 1:26 AM
Font : A-A+

New Epigenetic Compounds Show Promise in Patients With Lymphoma

Epigenetic compounds namely BET inhibitors and EZH2 inhibitors are found to be promising targets in lymphoma, revealed data presented at the TAT (Targeted Anticancer Therapies) International Congress 2018 in Paris, France. ESMO's phase-I oncology meeting featured early clinical studies with BET inhibitors and EZH2 inhibitors.

Dr Anastasios Stathis, head of the New Drugs Development Unit of the Oncology Institute of Southern Switzerland (IOSI), Bellinzona, Switzerland, was one of the first oncologists to conduct research in this field. He said BET inhibitors have shown some activity in leukaemia, lymphoma and also NUT carcinoma, a rare and aggressive solid tumour driven by a translocation involving BET genes. His previous phase I research on the first-in-class BET inhibitor birabresib (OTX015/MK-8628) showed some activity in diffuse large B-cell lymphoma, providing proof-of-concept for this approach. (1)

Advertisement


Subsequently birabresib was used on a single-patient compassionate basis in four patients with NUT carcinoma. Stathis said: "This was the first evidence that preclinical findings with BET inhibitors in models of NUT carcinoma could be translated into activity in patients." (2)

Since then multiple BET inhibitors have been studied in clinical trials and preliminary results have confirmed that they may be effective in patients with diffuse large B-cell lymphoma and NUT carcinoma. (3) Tolerability of these compounds has generally been good, but some side effects have been observed that may limit treatment compliance. Thrombocytopaenia which can be dose-limiting but is reversible and not accompanied by major bleeding events, fatigue and gastrointestinal symptoms have been the main side effects that have emerged so far.
Advertisement

Regarding activity, patients do eventually progress on treatment and the duration of response is unknown. Stathis said: "It's not clear what the real clinical impact of BET inhibitors could be. Compounds approved for lymphoma in the last five years had single-agent phase-I response rates above 30%, but activity with BET inhibitors is less than 30%. The hope is to identify the patients that would benefit most and test BET inhibitors in combination with other compounds. In addition, there are new classes of BET inhibitors in preclinical studies and we need to wait to see if they have better activity."

Another area where clinical data is emerging is related to EZH2 inhibitors for which data will be presented at TAT 2018. EZH2 is a protein that exhibits relatively frequent mutations in lymphoma. Results will be presented from a study in patients with B-cell lymphoma showing evidence of antitumour activity with an EZH2 inhibitor, which was well tolerated and had manageable toxicities. (4) Study author Dr Adrian Senderowicz of Constellation Pharmaceuticals, Cambridge, US, said: "If approved by health authorities, EZH2 inhibition may become a new treatment paradigm in relapse or refractory EZH2 mutant follicular lymphoma patients."

A previous study showed that another EZH2 inhibitor, tazemetostat, induced objective response rates of 92% in patients with EZH2 mutant follicular lymphoma and 26% in those with the wild-type. (5) Stathis said: "The question is whether it makes sense to treat patients without the mutation, since the response is so much lower. However, these patients do show some response and researchers want to know why."

Stathis said: "We do have proof, and we will see further evidence at TAT 2018, that epigenetics are a promising target in lymphomas."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
January is the Thyroid Awareness Month in 2022
Menstrual Disorders
Coffee May Help You Fight Endometrial Cancer
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chronic Lymphocytic Leukemia Epigenetics AIDS-HIV-Cancer Bone Marrow Transplantation 

Recommended Reading
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by ....
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....
Epigenetics
In the recent years 'epigenetics' represents inheritable changes in gene expression that do not ......
Age not Linked to Survival in Non-Hodgkin Lymphoma Patients
Age is not a limiting factor for Hematopoietic Cell Transplantation (HCT) in patients with ......
AIDS-HIV-Cancer
AIDS defining malignancies are cancers that occur in patients with AIDS due to their low immunity....
Bone Marrow Transplantation
Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are in...
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is consider...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
CONSULT A DOCTOR
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)