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New Drug to Treat Chemotherapy Overdose Receives FDA Approval

by Reshma Anand on December 14, 2015 at 12:15 PM
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New Drug to Treat Chemotherapy Overdose Receives FDA Approval

The most common complication faced by cancer patients is chemotherapy overdose. The drug used in chemotherapy 5-fluorouracil (5-FU) or capecitabine is known for causing severe toxicity affecting the cardiac or central nervous system and allergic reactions in patients.

The Food and Drug Administration (FDA) has recently approved a drug called Vistogard (uridine triacetate) for treating patients suffering from chemotherapy overdose. The drug has showed positive results in its final clinical trial.

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Uridine triacetate was tested on 135 adult and pediatric patients in two separate trials who had either overdosed on 5-FU or experienced life-threatening adverse events within 4 days of receiving 5-FU infusion therapy. Of those patients treated for overdose, 97% were alive after 30 days. Of those treated for toxicities, 89% were alive at 30 days.

The drug developed by Wellstat Therapeutics should be taken soon after overexposure - regardless of whether symptoms are present or early onset of severe toxicities, including severe mucositis, fever, diarrhea, or rash.

Source: Medindia
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