Vanderbilt University scientists have discovered a chemical bond that is essential for animal life and could lead to new therapies for cancer and other diseases.
The report, published online today by the Proceedings of the National Academy of Sciences(PNAS), was co-authored by 83 participants in the "Aspirnaut" K-20 STEM pipeline program for diversity. Six were middle school students when the study was conducted, 42 were high school students, 30 were college undergraduates and five were graduate students.
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Because many of the high school students grew up in poverty in rural communities, "they're invisible. They're an untapped talent pool," said Billy Hudson, Ph.D., who founded the Aspirnaut program with his wife and co-senior author Julie Hudson, M.D. "Aspirnaut connects the 'Forgotten Student' to STEM opportunities."
The study demonstrates that the sulfilimine bond, which Hudson's group discovered in 2009, is part of a "primordial innovation" dating back more than 500 million years to the ancestor of jellyfish. The bond stabilizes the collagen IV scaffold and is essential for more advanced tissue formation.
![Brain Tumor]( "Brain Tumor")
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors account for about 2.4% of all the tumor diagnosesandare most challenging due to their critically delicate location.
The bond is formed by hypohalous acids, a form of household bleach, generated by peroxidasin, an ancient enzyme embedded in the extracellular environment. This "oxidant generator" is key to forming new blood vessels that feed tumors, making it an attractive target for developing new drugs for cancer therapy, the researchers said.
The involvement of so many young students in a scientific publication is "rare, the first that I know of," said PNAS Editor-in-Chief Inder Verma, Ph.D. "It is a remarkable achievement," added Mina Bissell, Ph.D., who conducted the initial review of the manuscript for the journal.
During the summers of 2009 to 2013, the students participated in an "Expedition to the Dawn of the Animal Kingdom," a summer research program at Vanderbilt to search for the evolutionary origin of the sulfilimine chemical bond.
They contributed to experiments that showed the sulfilimine bond and the peroxidasin-based mechanism by which it forms can be traced to a common ancestor dating back more than 500 million years ago.
Of the 42 high-school researchers, 31 have now graduated. Thirty are attending or have completed college, 26 with STEM (science, technology, engineering and mathematics) majors.
Source: Eurekalert
Brain Tumor
Brain tumors are the abnormal growth of brain cells that may be benign or metastatic. Brain tumors account for about 2.4% of all the tumor diagnosesandare most challenging due to their critically delicate location.
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The bond is formed by hypohalous acids, a form of household bleach, generated by peroxidasin, an ancient enzyme embedded in the extracellular environment. This "oxidant generator" is key to forming new blood vessels that feed tumors, making it an attractive target for developing new drugs for cancer therapy, the researchers said.
The involvement of so many young students in a scientific publication is "rare, the first that I know of," said PNAS Editor-in-Chief Inder Verma, Ph.D. "It is a remarkable achievement," added Mina Bissell, Ph.D., who conducted the initial review of the manuscript for the journal.
During the summers of 2009 to 2013, the students participated in an "Expedition to the Dawn of the Animal Kingdom," a summer research program at Vanderbilt to search for the evolutionary origin of the sulfilimine chemical bond.
They contributed to experiments that showed the sulfilimine bond and the peroxidasin-based mechanism by which it forms can be traced to a common ancestor dating back more than 500 million years ago.
Of the 42 high-school researchers, 31 have now graduated. Thirty are attending or have completed college, 26 with STEM (science, technology, engineering and mathematics) majors.
Source: Eurekalert
Carcinoid Tumors
Carcinoid tumors is a benign tumor that results in carcinoid syndrome. Only 8 to 10% of all carcinoid tumors are associated with the carcinoid syndrome.
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 PheochromocytomaPheochromocytoma is a rare tumor of the adrenal glands that secretes the catecholamines, adrenaline and noradrenaline. Symptoms, diagnosis, treatment of adrenal gland tumor are explained in detail. | Advertisement
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