About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

New Bowel Cancer Drug Target Discovered

by Bidita Debnath on October 19, 2017 at 11:57 PM
Font : A-A+

New Bowel Cancer Drug Target Discovered

Bowel cancer is a general term for cancer that begins in the large bowel. Depending on where the cancer starts, bowel cancer is sometimes called colon or rectal cancer. Researchers have discovered a new drug target for bowel cancer that is specific to tumour cells and therefore less toxic than conventional therapies.

"There has long been a need to find more effective and less toxic drugs to treat bowel cancer," says Laura Novellasdemunt, first author of the paper and researcher at the Francis Crick Institute. "We have found a novel drug target that could provide the basis for a better therapy in patients in the future."

Advertisement


Most bowel cancers are caused by a mutation in a gene called APC that in its healthy form acts to prevent cancer formation. Mutated APC genes cause excess activity of a cell signalling pathway called 'Wnt', which has been associated with bowel cancer for over 20 years.

Wnt signalling is vital for many organs, so drugs designed to block Wnt signalling in cancer cause very toxic side effects in other parts of the body. This has been a major hurdle in developing effective and safe bowel cancer therapies. The team at the Crick have found a way to exclusively target Wnt signalling in tumour cells, that reduces growth of tumours derived from colon cancer cells without the toxic effects on healthy cells. Their findings will be published in Cell Reports.
Advertisement

The team used the gene-editing tool CRISPR to cut the APC gene at various positions, and found a crucial part of the gene that causes dangerous levels of Wnt signalling and cancer formation.

Using a number of molecular techniques, they identified a protein involved in over activation of the Wnt pathway in cancer. Preventing the activity of this protein by genetic deletion or blocking it with drugs caused a reduction in Wnt signalling in cancer cells and slowed down tumour growth in mice. Importantly, the drug was found to act exclusively on the tumour cells, and have no effect on Wnt signalling in healthy cells.

"Current treatment for bowel cancer is mostly generic, while targeted therapy will help future development of personalised medicine," says Vivian Li, senior author of the paper and Group Leader at the Francis Crick Institute. "The protein that we've identified holds great promise as a therapeutic target for bowel cancer treatment."

The next step will be to see if deleting the gene that makes the protein in mice will prevent them from developing bowel cancer. This will provide further evidence that the protein is a viable anti-cancer drug target.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Black Tea Protects against Blood Pressure and Heart Diseases
Green Mediterranean Diet may Help Repair Age-Related Brain Damages
Cervical Cancer Awareness Month 2022
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Cancer and Homeopathy Signature Drug Toxicity Cancer Facts Cancer Tattoos A Body Art Crohns Disease Drugs Banned in India Small Intestinal Cancer Oncology Drug Delivery Systems 

Recommended Reading
Existing Illnesses may Delay Bowel Cancer Diagnosis
During cancer diagnosis, other diseases can be a distraction because they also require attention or ...
Eating Omega-3 Rich Foods May Help Fight Bowel Cancer
Bowel cancer is the development of cancer from the colon or rectum. Foods that contain omega-3 rich ...
Predicting Bowel Cancer Survival Accurately
Bowel cancer means cancer that starts in the colon (large bowel) or back passage (rectum). It is ......
Low Complication Rates In Colonoscopy Screening For Bowel Cancer
Bowel cancer is the most common cancer. It also the 4th most common cause of death and the risk for ...
Crohns Disease
Crohn’s disease or regional enteritis is an inflammatory bowel disease that involves the small intes...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....
Oncology Drug Delivery Systems
Drug delivery in oncology offers a localized, prolonged and protected drug interaction with the canc...
Small Intestinal Cancer
Learn all about the early signs, symptoms, prevention and treatment of small intestine cancer....
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)