Baicalin is a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi. It has been shown to effectively inhibit cell apoptosis. Colistin sulfate, a cyclic cationic polypeptide antibiotic, has been shown to have renal and neurological side effects. Dr. Hong Jiang and colleagues from Northeast Agricultural University assumed that baicalin would suppress colistin sulfate-induced neuronal apoptosis. In a study by Jiang et al, PC12 cells were pretreated with baicalin (25, 50 and 100 μg/mL), and exposed to 125 μg/mL colistin sulfate. Cell morphology markedly changed, and cell viability increased. Moreover, caspase-3 activity, lactate dehydrogenase level and free radical content decreased. Experimental results indicated that baicalin inhibited colistin sulfate-induced PC12 cell apoptosis by suppressing free radical injury, and reducing caspase-3 activity and lactate dehydrogenase activity. These findings are published in the Neural Regeneration Research (Vol. 8, No. 28, 2013). Source: Eurekalert << Crocodiles are Cleverer Than Previously Thought: University... It is Possible To Shrink Tumors and Amplify Effectiveness o... >> Recommended Reading Genetic Mechanism To Convert Cells into Insulin Producers Identiied Experimenting on mice, a research team has found a way to convert another type of pancreas cell into the critical insulin-producing beta cells, which are lost in type I diabetes patients. READ MORE Wearable Solar Cells To Charge Gadgets on the Move Developed Charging gadgets while on the move may soon be possible, as scientists have developed a flexible solar cell that can be built into clothing. READ MORE Human Stem Cells Predict Efficacy of Alzheimer Medication Why do certain Alzheimer medications not work in clinical trials in humans but work in animal models? READ MORE Most Popular on Medindia Drug Interaction Checker Iron Intake Calculator Blood Donation - Recipients
Baicalin is a type of flavonoid extracted from the dried root of Scutellaria baicalensis georgi. It has been shown to effectively inhibit cell apoptosis. Colistin sulfate, a cyclic cationic polypeptide antibiotic, has been shown to have renal and neurological side effects. Dr. Hong Jiang and colleagues from Northeast Agricultural University assumed that baicalin would suppress colistin sulfate-induced neuronal apoptosis. In a study by Jiang et al, PC12 cells were pretreated with baicalin (25, 50 and 100 μg/mL), and exposed to 125 μg/mL colistin sulfate. Cell morphology markedly changed, and cell viability increased. Moreover, caspase-3 activity, lactate dehydrogenase level and free radical content decreased. Experimental results indicated that baicalin inhibited colistin sulfate-induced PC12 cell apoptosis by suppressing free radical injury, and reducing caspase-3 activity and lactate dehydrogenase activity. These findings are published in the Neural Regeneration Research (Vol. 8, No. 28, 2013). Source: Eurekalert << Crocodiles are Cleverer Than Previously Thought: University... It is Possible To Shrink Tumors and Amplify Effectiveness o... >> Recommended Reading Genetic Mechanism To Convert Cells into Insulin Producers Identiied Experimenting on mice, a research team has found a way to convert another type of pancreas cell into the critical insulin-producing beta cells, which are lost in type I diabetes patients. READ MORE Wearable Solar Cells To Charge Gadgets on the Move Developed Charging gadgets while on the move may soon be possible, as scientists have developed a flexible solar cell that can be built into clothing. READ MORE Human Stem Cells Predict Efficacy of Alzheimer Medication Why do certain Alzheimer medications not work in clinical trials in humans but work in animal models? READ MORE Most Popular on Medindia Drug Interaction Checker Iron Intake Calculator Blood Donation - Recipients
