A new study published in the journal Chemistry & Biology reveals that the buildup of fat in the body could be encouraged by naturally occurring steroids called glucocorticoids which interfere in the workings of cellular proteins called androgen receptors that are vital for blocking fat accumulation.
"This has implications in this era of an obesity epidemic," says senior author Dr. Michael Mancini, from Baylor College of Medicine. "If you can reduce glucocorticoids, you might be able to upregulate, or increase, androgen receptor activity and regulate fat storage."
The discovery came after Dr. Mancini and his team searched for genes or signals expressed specifically by human fat cells with the hope of gaining a better understanding of fat deposition and the development of obesity. They used a novel approach that combined gene expression studies with automated microscopy and specialized image analyses.
The researchers also found that glucocorticoids decrease androgen receptor activity and alter the effects of androgens on fat storage. The result is deposition of fat throughout the body, particularly in the abdominal region. "Using a custom-developed image analysis software platform usually found only in large pharmaceutical screening centers, we applied specific algorithms to sensitively detect the glucocorticoid inhibition of androgen receptor activity," says Dr. Mancini.
The research suggests that treatment strategies that modulate the activity of glucocorticoids and the androgen receptor—perhaps in combination—may help combat obesity.