About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Nasal Mucosal Inhalation of Alzheimer's Disease Vaccine Attenuates Aβ1-42-induced Cytotoxicity

by Bidita Debnath on July 12, 2014 at 10:13 PM
Font : A-A+

 Nasal Mucosal Inhalation of Alzheimer's Disease Vaccine Attenuates Aβ1-42-induced Cytotoxicity

N-methyl-D-aspartate receptor antagonists and cholinergic inhibitors can alleviate the symptoms of Alzheimer's disease.

But it fails to affect irreversible cognitive dysfunction and effectively scavenge amyloid beta peptide in the brain. Amyloid beta peptide (Aβ) vaccines reduced and eliminated Aβ deposition in an Alzheimer's disease (AD) transgenic mouse model, and significantly improved behavioral and cognitive impairment.

Advertisement

Dr. Yunpeng Cao and his team, First Affiliated Hospital of China Medical University, China immunized AD transgenic mouse models with Plp-Adeno-X-CMV-(Aβ3-10)10-CpG via nasal mucosal inhalation. They found that Plp-Adeno-X-CMV-(Aβ3-10)10-CpG vaccine can produce strong T helper 2 humoral immune responses, and avoid Aβ1-42-caused T helper 1 immune responses and Aβ1-42-induced cytotoxicity.

Therefore, Plp-Adeno-X-CMV-(Aβ3-10)10-CpG vaccine can be used as a novel type of AD vaccine. These findings were published in Neural Regeneration Research (Vol. 9, No. 8, 2014).

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Alzheimers Disease Vaccination for Children Diet and Alzheimer´s Disease Top 10 Vaccine Myths Debunked Genetics of Alzheimer´s disease Mini-Mental Scale (Cognitive Function Test) 

Most Popular on Medindia

Blood Pressure Calculator Sinopril (2mg) (Lacidipine) Noscaphene (Noscapine) Drug Interaction Checker Find a Hospital Blood - Sugar Chart Accident and Trauma Care Find a Doctor Drug - Food Interactions Vent Forte (Theophylline)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Nasal Mucosal Inhalation of Alzheimer's Disease Vaccine Attenuates Aβ1-42-induced Cytotoxicity Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests