About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Nanoparticles Designed To Treat Intestinal Inflammation

by Shirley Johanna on April 8, 2016 at 6:30 PM
Font : A-A+

Nanoparticles Designed To Treat Intestinal Inflammation

Inflammatory bowel disease (IBD) can be treated with nanoparticles designed to block a cell-surface molecule that plays a key role in inflammation, according to researchers at the Institute for Biomedical Sciences at Georgia State University and Southwest University in China.

The scientists developed nanoparticles, or microscopic particles, to reduce the expression of CD98, a glycoprotein that promotes inflammation. Their findings are published in the journal Colloids and Surfaces B: Biointerfaces.

Advertisement


"Our results suggest this nanoparticle could potentially be used as an efficient therapeutic treatment for inflammation," said Didier Merlin, professor in the Institute for Biomedical Sciences at Georgia State and researcher at the Atlanta Veterans Affairs Medical Center. "We targeted CD98 because we determined in a previous study that CD98 is highly over-expressed in activated immune cells involved in IBD."

In the United States, as many as 1.3 million people suffer from IBD, which includes ulcerative colitis and Crohn's disease, conditions with chronic or recurring abnormal response to the body's immune system and inflammation of the gastrointestinal tract. IBD gets worse over time and causes severe gastrointestinal symptoms, such as persistent diarrhea, cramping abdominal pain, fever, rectal bleeding, loss of appetite and weight loss. Surgery is required when medication can no longer control the symptoms, and patients also have an increased risk of colon cancer, according to the Centers for Disease Control and Prevention.
Advertisement

This study suggests the development of nanotherapeutic strategies could be an alternative to currently available drugs, which are limited by serious side effects, in treating inflammatory conditions such as IBD.

In the study, researchers formed the nanoparticles by combining CD98 siRNA, small interfering RNA that inhibits CD98 gene expression in macrophages (immune cells involved in IBD), with urocanic acid-modified chitosan (UAC). Chitosan is a polysaccharide obtained from the hard outer skeleton of shellfish. When introduced to macrophages, the nanoparticles had an anti-inflammatory effect on these immune cells.

Researchers found the nanoparticles had a desirable particle size and no apparent toxicity against macrophages and colon epithelial cells. Cell studies showed nanoparticles with a weight ratio of 60:1 (UAC:siCD98) had the best anti-inflammatory capacity.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Disability Day 2022 - The Role of Innovative Transformation
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
View all
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Nanotechnology 

Most Popular on Medindia

Sanatogen How to Reduce School Bag Weight - Simple Tips Accident and Trauma Care The Essence of Yoga Loram (2 mg) (Lorazepam) A-Z Drug Brands in India Drug Interaction Checker Noscaphene (Noscapine) Iron Intake Calculator Find a Doctor
open close
CONSULT ONLINE WITH A DOCTOR

×

Nanoparticles Designed To Treat Intestinal Inflammation Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests