About Careers Internship MedBlog Contact us

Men More at Risk of Dying From Heart Failure Than Women

by VR Sreeraman on March 10, 2012 at 5:36 PM
 Men More at Risk of Dying From Heart Failure Than Women

Women with chronic heart failure may live longer than their male counterparts, researchers have said.

The large analysis of studies comprising data on more than 40,000 subjects represents the largest assessment of gender and mortality risk in heart failure, and provides evidence which many randomised trials have failed to do because they have been dominated by male patients.


Heart failure is by far the single biggest reason for acute hospital admission. Its incidence is still increasing - more cases are being identified, more people are living to an old age, and more are surviving a heart attack but with damage to the heart muscle.

The condition arises when the heart fails to pump sufficient blood to meet the body's demands. The common symptoms of heart failure - shortness of breath, tiredness, oedema - are usually associated with failure of the left side of the heart, as defined by a measurement known as left ventricular ejection fraction.

The latest study also found that heart failure patients whose ejection fraction is not reduced have a lower mortality risk that those with reduced ejection fraction.

According to the authors, preserved ejection fraction is more common among women than men, and this "may be expected to lead to better survival for these patients".

The study analysed data from 31 randomised and observational studies involving 28,052 men and 13,897 women with chronic heart failure.

The data were analysed for survival over three years of follow-up, and showed that 25.3 percent of the women and 25.7 percent of the men died during the three years, this represented a death rate of 137 deaths per 1000 patient-years in men and 135 per 100 patient-years in women.

When adjusted for age, however, the results showed that men had a 31 percent higher risk of death than women, and that male gender was an independent risk factor for death at three years.

The authors said that the study was "appropriately powered to ascertain the prognostic significance of sex in patients with heart failure".

This excess mortality risk associated with male gender was of similar magnitude in patients with either reduced or preserved ejection fraction, which was not affected by either age or history of hypertension.

"This study has clearly demonstrated that survival is better for women with heart failure than for men, irrespective of ejection fraction, age or other variables," Manuel Martinez-Selles, first author of the study from the Gregorio Maranon University Hospital in Madrid, said.

"This survival benefit is inherent to female sex and there are a number of potential explanations for the better outcomes in women. The female heart appears to respond to injury differently from the male heart.

For example, women have less ventricular remodelling, greater preservation of right ventricular function, and greater protection against ventricular arrhythmias, neurohormonal activation, genetic mutations, and apoptosis. Some of these advantages could be related to pregnancy and to sex-specific differences in gene expression," Martinez-Selles added.

The study has been published in the European Journal of Heart Failure.

Source: ANI
Font : A-A+



Recommended Readings

Latest Menīs Health News

Remodelling Signal Pathways in Prostate Cancer - A New Therapeutic Target!
Prostate cancer mutations targeting PI3K signaling are greatly influenced by PLEKHS1, a protein, enhances cancer drug therapy efficiency.
Treating Urinary Symptoms in Elderly Men may Reduce Mortality Risk
A substantial reduction in mortality risk was found in older men taking medications for lower urinary tract symptoms (LUTS).
One-Third of Men Worldwide Infected With Genital HPV
Men's human papillomavirus (HPV) infections underscore the importance of their participation in efforts to reduce HPV-related diseases in all genders.
Next-gen Treatment Eases Enlarged Prostate Symptoms
Men who received active Optilume treatment demonstrated more significant improvement in symptoms related to benign prostatic hyperplasia.
How Sperm Formation May Impact Fertility?
Investigation of sperm formation and its molecular intricacies reveals a potential connection between infertility and alterations in sperm amino acids.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

Men More at Risk of Dying From Heart Failure Than Women Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests