In teenagers, early-life exposure to mineral manganese was found to affect cognitive ability and motor control connect, reported Mount Sinai researchers report in a study published in PLOS ONE in August.
Researchers found links between early-life manganese exposure and altered functional connectivity of brain areas that support cognitive and motor control, potentially leading to low IQ, attention disorders, and hyperactivity.
"These findings could inform prevention and intervention efforts to reduce these poor outcomes in adolescents exposed to high levels of manganese," said Erik de Water, the first author and a postdoctoral fellow in the Department of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai.
They used functional magnetic resonance imaging (fMRI) scans to measure intrinsic functional connectivity of the brain in adolescents. Higher manganese concentrations in the first year of life were associated with increased intrinsic functional connectivity within cognitive control brain areas, but decreased connectivity between motor areas in adolescents.