Planar 99mTc-labeled RBC scintigraphy is sensitive for detection of acute gastrointestinal (GI) bleeding but its accuracy for localization of a bleeding source is arguable, particularly in patients with complex GI anatomy from prior surgeries.
Researchers at the Cleveland Clinic reviewed cases of GI bleeding in patients who had a concurrent hybrid SPECT-CT for evaluating equivocal 99mTc-labeled RBC activity on planar scintigraphy. Of those patients whose GI bleeding (as opposed to abdominal RBC activity due to other causes) was confirmed, SPECT-CT was 100 percent accurate in identifying the location of the bleeding.
"Judicious utilization of hybrid SPECT-CT for localization of the site of GI bleeding has the potential to improve clinical care by eliminating the ambiguities of planar scintigraphy," said researcher Ajit Goenka. "Based on the performance of SPECT-CT in this study, we are [working] to make it a routine practice at our institution."