It has been seen that large burns can trigger multitudes of problems like cardiac problems, enhanced inflammatory and hypermetabolic responses in patients. Treatment has to be focused on not the burn but also on these problems.
In case of the burn it results in immediate, dramatic inflammatory response. It can also cause depletion of essential proteins, reduced bone density and muscle strength, and can compromise the function of vital organs. Severe burn also causes increased mortality in burnt patients. The researchers are still trying to analyze the roles played by inflammation and hypermetabolism in burns.
Burns
Burn injuries have reached epidemic proportions in recent years. Burn accident statistics show that at least 50% of all burn accidents can be prevented.
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Marc G. Jeschke from Shriners Hospitals for Children, Texas, USA and colleagues conducted a prospective clinical trial of 189 paediatric burned patients over nine years to see if burn size is associated with differences in inflammation, body composition, protein synthesis and organ function.
Burn injuries involving more than 80% of the total body surface cause marked and prolonged inflammation, increases in hypermetabolism, catabolism, cardiac dysfunction and subsequently higher incidences of infection, sepsis and death. These effects were burn size-dependent.
![Burns - First Aid and Emergency Treatment Guide]( "Burns - First Aid and Emergency Treatment Guide")
A quick and simple first aid guide on how to administer treatment for first degree and second degree minor burns. Third Degree Burns usually require hospitalization.
Another outstanding finding was that effect of burn size on cardiac dysfunction. Only large burns caused cardiac dysfunction which was shown by Pereira et al. as one of the major contributor to mortality, implying the importance of adequate cardiovascular support and treatment.
Patients with larger burns also had higher levels of pro-inflammatory cytokines, such as Tumor Necrosis Factor and Interleukin-8. The authors think these give the inflammatory response an added boost, enhancing catabolism and hypermetabolism.
Source: Eurekalert
BIN/J
Burns - First Aid and Emergency Treatment Guide
A quick and simple first aid guide on how to administer treatment for first degree and second degree minor burns. Third Degree Burns usually require hospitalization.
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Another outstanding finding was that effect of burn size on cardiac dysfunction. Only large burns caused cardiac dysfunction which was shown by Pereira et al. as one of the major contributor to mortality, implying the importance of adequate cardiovascular support and treatment.
Patients with larger burns also had higher levels of pro-inflammatory cytokines, such as Tumor Necrosis Factor and Interleukin-8. The authors think these give the inflammatory response an added boost, enhancing catabolism and hypermetabolism.
Source: Eurekalert
BIN/J
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