About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Key Protein Responsible for Controlling Communication Between Brain Cells Discovered

by Sheela Philomena on November 30, 2013 at 10:19 AM
Font : A-A+

 Key Protein Responsible for Controlling Communication Between Brain Cells Discovered

Scientists have revealed how some of the brain's 100 billion nerve cells co-ordinate their communication.

The University of Bristol research team investigated some of the chemical processes that underpin how brain cells co-ordinate their communication. Defects in this communication are associated with disorders such as epilepsy, autism and schizophrenia, and therefore these findings could lead to the development of novel neurological therapies.

Advertisement

Neurons in the brain communicate with each other using chemicals called neurotransmitters. This release of neurotransmitter from neurons is tightly controlled by many different proteins inside the neuron. These proteins interact with each other to ensure that neurotransmitter is only released when necessary. Although the mechanisms that control this release have been extensively studied, the processes that co-ordinate how and when the component proteins interact is not fully understood.

The School of Biochemistry researchers have now discovered that one of these proteins called 'RIM1α' is modified by a small protein named 'SUMO' which attaches to a specific region in RIM1α. This process acts as a 'molecular switch' which is required for normal neurotransmitter release.
Advertisement

Jeremy Henley, Professor of Molecular Neuroscience in the University's Faculty of Medical and Veterinary Sciences and the study's lead author, said: "These findings are important as they show that SUMO modification plays a vital and previously unsuspected role in normal brain function."

The research builds on the team's earlier work that identified a group of proteins in the brain responsible for protecting nerve cells from damage and could be used in future for therapies for stroke and other brain diseases.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment Brain Brain Facts Ataxia Magical Millets for Your Health Diet and Nutrition Tips for Athletes Nutrition IQ Language Areas in The Brain Ways to Improve your Intelligence Quotient (IQ) 

Recommended Reading
Epilepsy
Fits or convulsions or Epilepsy is characterized by recurrent, involuntary seizures and is ......
Schizophrenia
Schizophrenia is a mental disorder characterized by symptoms of thought, behavior and social ......
Brain Depression - Animation
Interactive section of Medindia provides information about chemistry of Brain depression...
Quiz on Brain
The human brain is exquisitely intrinsic and is the seat of all emotions. If you are curious about ....
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Diet and Nutrition Tips for Athletes
Athletes can be physically fit by consuming a well balanced nutritious diet, which keeps them mental...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Magical Millets for Your Health
Millets are far more nutrient dense than wheat and rice. They are inexpensive and tasty too. Nutriti...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...
Ways to Improve your Intelligence Quotient (IQ)
Intelligence quotient (IQ) is a psychological measure of human intelligence. Regular physical and me...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use