Researchers at Hebrew University in Jerusalem may have found the answer to drug-resistant bacteria after finding the mechanism through which they are able to survive the antibacterial treatment.
The researchers found that when antibiotics attack these bacteria, the HipA toxin - naturally occurring toxin triggering dormancy of the bacteria - disrupts the chemical "messaging" process necessary for nutrients to build proteins.
Bacteria treat this condition as 'hunger signal', go into an inactive state in which they are able to survive until the antibacterial treatment is over and they can resume their harmful activity, said the research published in the journal Nature Communications.
Until now, it had been known that there is a connection between these kind of bacteria and the naturally occurring toxin HipA in the bacteria, but scientists did not know the cellular target of this toxin and how its activity triggers dormancy of the bacteria, added the research.
The research on persistent bacteria, being conducted in Balaban's lab for several years, would be combined with the work being done in Glaser's lab focusing on combating persistent bacteria - leading to more effective treatment for bacterial infections.