Intensive glucose control, a common approach to achieve low blood sugar targets in type 2 diabetes can increase the risk of mortality, reports a study by Cardiff University.
Looking at routine data from over 300,000 people in the UK, collected between 2004 and 2015, researchers found that lower levels of glycated haemoglobin--typically regarded as being good diabetes control - were associated with increased mortality risk, compared to moderate levels, especially in conjunction with intensive treatments that could cause hypoglycaemia.
Professor Craig Currie from Cardiff University's School of Medicine said: "Treatment guidelines generally recommend therapeutic strategies that aim for low levels of glucose control, on the understanding that it reduces risk of macrovascular complications such as coronary artery disease and stroke. Contrary to this belief, our findings show persuasively that there is an association with increased mortality risk and what is considered to be good glucose control, or low HbA1c."
Professor Currie said: "Serious questions remain about the safety of some glucose lowering drugs, with scientific evidence and opposing opinions being largely ignored."